{"id":64850,"date":"2023-02-06T20:38:36","date_gmt":"2023-02-06T13:38:36","guid":{"rendered":"https:\/\/asprou.com\/?p=64850"},"modified":"2023-04-06T15:46:37","modified_gmt":"2023-04-06T08:46:37","slug":"airsupra-thuoc-moi-dieu-tri-hen-suyen","status":"publish","type":"post","link":"https:\/\/asprou.com\/khoa-duoc\/airsupra-thuoc-moi-dieu-tri-hen-suyen\/","title":{"rendered":"AIRSUPRA \u2013 THU\u1ed0C M\u1edaI \u0110I\u1ec0U TR\u1eca HEN SUY\u1ec4N"},"content":{"rendered":"\n

1. Gi\u1edbi thi\u1ec7u<\/strong><\/p>\n\n\n\n

Hen suy\u1ec5n l\u00e0 m\u1ed9t b\u1ec7nh vi\u00eam \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p m\u00e3n t\u00ednh v\u1edbi c\u00e1c tri\u1ec7u ch\u1ee9ng kh\u00e1c nhau, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn 262 tri\u1ec7u ng\u01b0\u1eddi tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. \u1ede Hoa K\u1ef3, h\u01a1n 21 tri\u1ec7u ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh m\u1eafc b\u1ec7nh hen suy\u1ec5n, chi\u1ebfm h\u01a1n 80% t\u1ed5ng s\u1ed1 ng\u01b0\u1eddi m\u1eafc b\u1ec7nh hen suy\u1ec5n. Ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh c\u00f3 8,5 tri\u1ec7u \u0111\u1ee3t k\u1ecbch ph\u00e1t m\u1ed7i n\u0103m \u1edf Hoa K\u1ef3. \u1ede Vi\u1ec7t Nam, 3,9% d\u00e2n s\u1ed1 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 4 tri\u1ec7u ng\u01b0\u1eddi m\u1eafc b\u1ec7nh.<\/p>\n\n\n\n

Ng\u00e0y 11 th\u00e1ng 1 n\u0103m 2023, Airsupra (albuterol\/budesonide), \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t \u1edf Hoa K\u1ef3 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ho\u1eb7c ph\u00f2ng ng\u1eeba co th\u1eaft ph\u1ebf qu\u1ea3n khi c\u1ea7n thi\u1ebft v\u00e0 gi\u1ea3m nguy c\u01a1 b\u00f9ng ph\u00e1t b\u1ec7nh \u1edf nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh hen suy\u1ec5n t\u1eeb 18 tu\u1ed5i tr\u1edf l\u00ean.<\/p>\n\n\n\n

Airsupra l\u00e0 s\u1ea3n ph\u1ea9m \u0111\u1ea7u ti\u00ean c\u00f3 ch\u1ee9a ICS \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn \u1edf Hoa K\u1ef3 nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u1eaft c\u01a1n (ch\u1ee9 kh\u00f4ng ph\u1ea3i l\u00e0 thu\u1ed1c ki\u1ec3m so\u00e1t) b\u1ec7nh hen suy\u1ec5n. Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m gi\u00e3n c\u01a1 v\u00e0 gi\u1ea3m vi\u00eam trong \u0111\u01b0\u1eddng d\u1eabn kh\u00ed \u1edf ph\u1ed5i \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 l\u00ean c\u01a1n hen n\u1eb7ng. Airsupra \u0111\u01b0\u1ee3c d\u00f9ng d\u01b0\u1edbi d\u1ea1ng hai l\u1ea7n h\u00edt b\u1eb1ng mi\u1ec7ng k\u1ebft h\u1ee3p gi\u1eefa albuterol 90 mcg v\u00e0 budesonide 80 mcg m\u1ed7i l\u1ea7n h\u00edt (t\u1ed5ng li\u1ec1u albuterol 180 mcg v\u00e0 budesonide 160 mcg) khi c\u1ea7n thi\u1ebft cho c\u00e1c tri\u1ec7u ch\u1ee9ng hen suy\u1ec5n.<\/p>\n\n\n\n

2. C\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng<\/strong><\/p>\n\n\n\n

Airsupra k\u1ebft h\u1ee3p hai lo\u1ea1i thu\u1ed1c, m\u1ed9t lo\u1ea1i thu\u1ed1c ch\u1ee7 v\u1eadn beta2-adrenergic (SABA) t\u00e1c d\u1ee5ng ng\u1eafn\/t\u00e1c d\u1ee5ng nhanh (SABA) c\u00f3 t\u00ean l\u00e0 albuterol sulfat v\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c corticosteroid d\u1ea1ng h\u00edt (ICS) c\u00f3 t\u00ean l\u00e0 budesonide trong m\u1ed9t \u1ed1ng h\u00edt qua \u0111\u01b0\u1eddng mi\u1ec7ng, \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o \u0111\u01b0\u1eddng th\u1edf d\u01b0\u1edbi d\u1ea1ng b\u00ecnh x\u1ecbt \u0111\u1ea9y.<\/p>\n\n\n\n

Albuterol, c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 salbutamol, c\u00f3 ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb v\u00e0 ph\u00f2ng ng\u1eeba co th\u1eaft ph\u1ebf qu\u1ea3n (c\u1ea5p t\u00ednh ho\u1eb7c n\u1eb7ng) \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng th\u1edf c\u00f3 h\u1ed3i ph\u1ee5c, bao g\u1ed3m co th\u1eaft ph\u1ebf qu\u1ea3n do g\u1eafng s\u1ee9c. Albuterol t\u00e1c \u0111\u1ed9ng l\u00ean th\u1ee5 th\u1ec3 adrenergic beta-2 \u0111\u1ec3 l\u00e0m gi\u00e3n c\u01a1 tr\u01a1n ph\u1ebf qu\u1ea3n. N\u00f3 c\u0169ng \u1ee9c ch\u1ebf gi\u1ea3i ph\u00f3ng c\u00e1c ch\u1ea5t trung gian g\u00e2y qu\u00e1 m\u1eabn ngay l\u1eadp t\u1ee9c t\u1eeb c\u00e1c t\u1ebf b\u00e0o, \u0111\u1eb7c bi\u1ec7t l\u00e0 t\u1ebf b\u00e0o mast.<\/p>\n\n\n\n

Budesonide: Budesonide l\u00e0 m\u1ed9t corticosteroid ch\u1ed1ng vi\u00eam th\u1ec3 hi\u1ec7n ho\u1ea1t t\u00ednh glucocorticoid m\u1ea1nh. C\u01a1 ch\u1ebf c\u1ee7a t\u00e1c d\u1ee5ng c\u1ee7a ICS trong b\u1ec7nh hen suy\u1ec5n v\u1eabn ch\u01b0a r\u00f5 r\u00e0ng. Tuy nhi\u00ean, nhi\u1ec1u nghi\u00ean c\u1ee9u nh\u1eadn th\u1ea5y ICS c\u00f3 t\u00e1c d\u1ee5ng ch\u1ed1ng vi\u00eam m\u1ea1nh l\u00e0m gi\u1ea3m vi\u00eam v\u00e0 ph\u1ea3n \u1ee9ng qu\u00e1 m\u1ee9c (co th\u1eaft) c\u1ee7a \u0111\u01b0\u1eddng th\u1edf do hen suy\u1ec5n, l\u00e0m cho c\u01a1n hen \u00edt nghi\u00eam tr\u1ecdng h\u01a1n.<\/p>\n\n\n\n

3. Hi\u1ec7u qu\u1ea3<\/strong><\/p>\n\n\n\n

Hi\u1ec7u qu\u1ea3 c\u1ee7a Airsupra trong vi\u1ec7c gi\u1ea3m nguy c\u01a1 l\u00ean c\u01a1n hen n\u1eb7ng \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n hen suy\u1ec5n t\u1eeb trung b\u00ecnh \u0111\u1ebfn n\u1eb7ng trong MANDALA (NCT03769090), m\u1ed9t nghi\u00ean c\u1ee9u \u0111a trung t\u00e2m, m\u00f9 \u0111\u00f4i, ng\u1eabu nhi\u00ean. B\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ch\u1ecdn ng\u1eabu nhi\u00ean d\u00f9ng Airsupra 180 mcg\/160 mcg ho\u1eb7c albuterol 180 mcg v\u00e0 \u0111\u01b0\u1ee3c h\u01b0\u1edbng d\u1eabn d\u00f9ng khi c\u1ea7n thi\u1ebft \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c tri\u1ec7u ch\u1ee9ng hen suy\u1ec5n.<\/p>\n\n\n\n

Ti\u00eau ch\u00ed \u0111\u00e1nh gi\u00e1 ch\u00ednh v\u1ec1 hi\u1ec7u qu\u1ea3 l\u00e0 th\u1eddi \u0111i\u1ec3m xu\u1ea5t hi\u1ec7n c\u01a1n hen n\u1eb7ng \u0111\u1ea7u ti\u00ean (\u0111\u01b0\u1ee3c \u0111\u1ecbnh ngh\u0129a l\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng hen n\u1eb7ng l\u00ean ho\u1eb7c kh\u1edfi ph\u00e1t c\u1ea7n d\u00f9ng corticosteroid to\u00e0n th\u00e2n trong \u00edt nh\u1ea5t ba ng\u00e0y ho\u1eb7c nh\u1eadp vi\u1ec7n c\u1ea5p c\u1ee9u d\u1eabn \u0111\u1ebfn s\u1eed d\u1ee5ng corticosteroid to\u00e0n th\u00e2n trong \u00edt nh\u1ea5t ba ng\u00e0y ho\u1eb7c nh\u1eadp vi\u1ec7n \u00edt nh\u1ea5t 24 gi\u1edd do hen suy\u1ec5n).<\/p>\n\n\n\n

\u1ede nh\u1eefng b\u1ec7nh nh\u00e2n tr\u01b0\u1edfng th\u00e0nh, \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Airsupra, so v\u1edbi albuterol, \u0111\u00e3 ch\u1ee9ng minh gi\u1ea3m 28% nguy c\u01a1 l\u00ean c\u01a1n hen suy\u1ec5n nghi\u00eam tr\u1ecdng \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 theo th\u1eddi \u0111i\u1ec3m xu\u1ea5t hi\u1ec7n c\u01a1n hen suy\u1ec5n nghi\u00eam tr\u1ecdng \u0111\u1ea7u ti\u00ean.<\/p>\n\n\n\n

4. An to\u00e0n<\/strong><\/p>\n\n\n\n

C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn nh\u1ea5t c\u1ee7a Airsupra l\u00e0 \u0111au \u0111\u1ea7u, nhi\u1ec5m n\u1ea5m mi\u1ec7ng, ho v\u00e0 kh\u00f3 n\u00f3i.<\/p>\n\n\n\n

Tr\u00e1nh d\u00f9ng Airsupra \u1edf b\u1ec7nh nh\u00e2n qu\u00e1 m\u1eabn c\u1ea3m v\u1edbi albuterol, budesonide ho\u1eb7c v\u1edbi b\u1ea5t k\u1ef3 th\u00e0nh ph\u1ea7n b\u1ed5 sung n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n\n\n\n

B\u1ec7nh nh\u00e2n kh\u00f4ng d\u00f9ng qu\u00e1 s\u00e1u li\u1ec1u (12 l\u1ea7n h\u00edt) trong kho\u1ea3ng th\u1eddi gian 24 gi\u1edd.<\/p>\n\n\n\n

Th\u1eadn tr\u1ecdng khi s\u1eed d\u1ee5ng Airsupra \u1edf b\u1ec7nh nh\u00e2n b\u1ecb r\u1ed1i lo\u1ea1n tim m\u1ea1ch, r\u1ed1i lo\u1ea1n co gi\u1eadt, c\u01b0\u1eddng gi\u00e1p, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng v\u00e0 nhi\u1ec5m toan ceton.<\/p>\n\n\n\n

T\u00c0I LI\u1ec6U THAM KH\u1ea2O<\/strong><\/p>\n\n\n\n

1. The Global Asthma Network. The Global Asthma Report 2022. [Online]. Available at: <\/a>http:\/\/globalasthmareport.org\/index.html [Last accessed: November 2022].<\/p>\n\n\n\n

2. CDC. Most Recent National Asthma Data. [Online]\/ Available at: https:\/\/www.cdc.gov\/asthma\/most_recent_national_asthma_data.htm. [Last accessed: November 2022].<\/p>\n\n\n\n

3. Papi A, et al. Albuterol\u2013Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma. N Engl J Med 2022; 386 (22): 2071-2083.<\/p>\n\n\n\n

4. Chipps BE, et al. Efficacy and safety of albuterol\/budesonide (PT027) in mild-to-moderate asthma: Results of the DENALI study. Am J Respir Crit Care Med 2022; 205: A3414. Abstract. Available at: https:\/\/doi.org\/10.1164\/ajrccm-conference.2022.205.1_MeetingAbstracts.A3414 [Last accessed: November 2022].<\/a><\/p>\n\n\n\n

5. FDA approves drug combination treatment for adults with asthma. Available at: https:\/\/www.fda.gov\/drugs\/news-events-human-drugs\/fda-approves-drug-combination-treatment-adults-asthma<\/a> [Last accessed: February 2023].<\/p>\n\n\n\n

THS.DS. PH\u1ea0M C\u1ea2NH EM<\/p>\n\n\n\n

B\u1ed8 M\u00d4N H\u00d3A D\u01af\u1ee2C<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

1. Gi\u1edbi thi\u1ec7u Hen suy\u1ec5n l\u00e0 m\u1ed9t b\u1ec7nh vi\u00eam \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p m\u00e3n t\u00ednh v\u1edbi c\u00e1c tri\u1ec7u ch\u1ee9ng kh\u00e1c nhau, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn 262 tri\u1ec7u ng\u01b0\u1eddi tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. […]<\/p>\n","protected":false},"author":82,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":""},"categories":[1796,267,2267],"tags":[],"yoast_head":"\nAIRSUPRA \u2013 THU\u1ed0C M\u1edaI \u0110I\u1ec0U TR\u1eca HEN SUY\u1ec4N - Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Qu\u1ed1c t\u1ebf H\u1ed3ng B\u00e0ng<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/asprou.com\/khoa-duoc\/airsupra-thuoc-moi-dieu-tri-hen-suyen\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AIRSUPRA \u2013 THU\u1ed0C M\u1edaI \u0110I\u1ec0U TR\u1eca HEN SUY\u1ec4N - Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Qu\u1ed1c t\u1ebf H\u1ed3ng B\u00e0ng\" \/>\n<meta property=\"og:description\" content=\"1. 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