{"id":64034,"date":"2022-12-02T11:52:48","date_gmt":"2022-12-02T04:52:48","guid":{"rendered":"https:\/\/asprou.com\/?p=64034"},"modified":"2023-04-06T15:46:41","modified_gmt":"2023-04-06T08:46:41","slug":"sixmo-que-cay-ghep-duoi-da-tac-dung-keo-dai-buprenorphine","status":"publish","type":"post","link":"https:\/\/asprou.com\/khoa-duoc\/sixmo-que-cay-ghep-duoi-da-tac-dung-keo-dai-buprenorphine\/","title":{"rendered":"SIXMO\u00ae, QUE C\u1ea4Y GH\u00c9P D\u01af\u1edaI DA T\u00c1C D\u1ee4NG K\u00c9O D\u00c0I BUPRENORPHINE"},"content":{"rendered":"\n<p>Buprenorphine l\u00e0 ho\u1ea1t ch\u1ea5t \u0111ang \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ng\u00e0y c\u00e0ng r\u1ed9ng r\u00e3i trong c\u00e1c ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb l\u00e0m gi\u1ea3m c\u01a1n \u0111au li\u00ean t\u1ee5c v\u00e0 nghi\u00eam tr\u1ecdng (ch\u1eb3ng h\u1ea1n nh\u01b0 do vi\u00eam kh\u1edbp, \u0111au l\u01b0ng m\u00e3n t\u00ednh). v\u00e0 h\u1ed7 tr\u1ee3 cai nghi\u1ec7n c\u00e1c ch\u1ea5t d\u1ea1ng thu\u1ed1c phi\u1ec7n.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"268\" height=\"247\" src=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image.png\" alt=\"\" class=\"wp-image-64036\"\/><\/figure>\n\n\n\n<p>C\u00e1c c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m kh\u00f4ng ng\u1eebng nghi\u00ean c\u1ee9u ph\u00e1t tri\u1ec3n c\u00e1c d\u1ea1ng b\u00e0o ch\u1ebf cho ho\u1ea1t ch\u1ea5t Buprenorphine nh\u01b0:<\/p>\n\n\n\n<p><strong>Norspan<sup>\u00ae<\/sup><\/strong> Mi\u1ebfng d\u00e1n gi\u1ea3i ph\u00f3ng thu\u1ed1c qua da (Transdermal Patch) ch\u1ee9a Buprenorphine nhi\u1ec1u h\u00e0m l\u01b0\u1ee3ng 5\/10\/20\/40mg, \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf gi\u1ea3i ph\u00f3ng thu\u1ed1c trong v\u00f2ng 3-7 ng\u00e0y.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"366\" height=\"391\" src=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-1.png\" alt=\"\" class=\"wp-image-64037\" srcset=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-1.png 366w, https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-1-281x300.png 281w\" sizes=\"(max-width: 366px) 100vw, 366px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"231\" height=\"230\" src=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-2.png\" alt=\"\" class=\"wp-image-64038\" srcset=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-2.png 231w, https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-2-150x150.png 150w, https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-2-175x175.png 175w, https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-2-165x165.png 165w\" sizes=\"(max-width: 231px) 100vw, 231px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"367\" height=\"218\" src=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-3.png\" alt=\"\" class=\"wp-image-64039\" srcset=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-3.png 367w, https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-3-300x178.png 300w\" sizes=\"(max-width: 367px) 100vw, 367px\" \/><\/figure>\n\n\n\n<p>Vi\u00ean n\u00e9n ng\u1eadm d\u01b0\u1edbi l\u01b0\u1ee1i (siblingual tablets): ch\u1ee9a 2,16 mg Buprenorphine hydrochloride t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 2mg Buprenorphine, c\u00f9ng m\u1ed9t s\u1ed1 t\u00e1 d\u01b0\u1ee3c v\u1eeba \u0111\u1ee7 1 vi\u00ean<\/p>\n\n\n\n<p>Thu\u1ed1c ti\u00eam: ch\u1ee9a 300 microgram Buprenorphine d\u1ea1ng mu\u1ed1i hydrochloride trong 1ml d\u00f9ng ti\u00eam b\u1eafp ho\u1eb7c ti\u00eam t\u0129nh m\u1ea1ch<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"387\" height=\"206\" src=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-4.png\" alt=\"\" class=\"wp-image-64040\" srcset=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-4.png 387w, https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-4-300x160.png 300w\" sizes=\"(max-width: 387px) 100vw, 387px\" \/><\/figure>\n\n\n\n<p>Tuy nhi\u00ean, c\u00e1c d\u1ea1ng b\u00e0o ch\u1ebf t\u1eeb Buprenorphine d\u1ea1ng ng\u1eadm d\u01b0\u1edbi l\u01b0\u1ee1i sang ti\u00eam d\u1eabn \u0111\u1ebfn m\u1ed9t s\u1ed1 bi\u1ebfn ch\u1ee9ng c\u1ee5 th\u1ec3 nh\u01b0 k\u00edch \u1ee9ng da, \u00e1p xe ch\u1ed7 ti\u00eam, vi\u00eam n\u1ed9i t\u00e2m m\u1ea1c. H\u01a1n n\u1eefa, h\u00ecnh th\u1ee9c \u0111i\u1ec1u tr\u1ecb hi\u1ec7n t\u1ea1i \u0111\u00f2i h\u1ecfi ph\u1ea3i u\u1ed1ng h\u00e0ng ng\u00e0y, g\u00e2y kh\u00f3 kh\u0103n, b\u1ea5t ti\u1ec7n.<\/p>\n\n\n\n<p>V\u00ec t\u1ea5t c\u1ea3 nh\u1eefng l\u00fd do n\u00e0y, c\u00e1c c\u00f4ng th\u1ee9c m\u1edbi c\u1ee7a buprenorphine ph\u00f3ng th\u00edch k\u00e9o d\u00e0i (XR-BUP) nh\u01b0 Buvidal <sup>\u00ae<\/sup> (Camurus \u00ae , Th\u1ee5y \u0110i\u1ec3n) v\u00e0 Sublocade \u00ae (Indivior \u00ae , Hoa K\u1ef3) \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u00e0 th\u01b0\u01a1ng m\u1ea1i h\u00f3a, cung c\u1ea5p ph\u1ea1m vi \u0111i\u1ec1u tr\u1ecb trong m\u1ed9t tu\u1ea7n, m\u1ed9t th\u00e1ng ho\u1eb7c s\u00e1u th\u00e1ng cho c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng cai nghi\u1ec7n opioid.<\/p>\n\n\n\n<p>B\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 nghi\u00ean c\u1ee9u v\u1edbi s\u1ef1 ra \u0111\u1eddi c\u1ee7a que c\u1ea5y d\u01b0\u1edbi da Probuphine v\u1edbi nh\u00e3n hi\u1ec7u Sixmo <sup>\u00ae<\/sup> , \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t \u1edf Hoa K\u1ef3 v\u00e0 Ch\u00e2u \u00c2u. Probuphine l\u00e0 thi\u1ebft b\u1ecb c\u1ea5y d\u01b0\u1edbi da duy nh\u1ea5t \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 cung c\u1ea5p buprenorphine li\u00ean t\u1ee5c trong s\u00e1u th\u00e1ng sau khi c\u1ea5y.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"369\" height=\"387\" src=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-5.png\" alt=\"\" class=\"wp-image-64041\" srcset=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-5.png 369w, https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-5-286x300.png 286w\" sizes=\"(max-width: 369px) 100vw, 369px\" \/><\/figure>\n\n\n\n<p><strong>1. D\u1ea1ng b\u00e0o ch\u1ebf<\/strong><\/p>\n\n\n\n<p>Probuphine \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng ProNeura\u2122, h\u1ec7 th\u1ed1ng ph\u00e2n ph\u1ed1i thu\u1ed1c li\u00ean t\u1ee5c do Titan ph\u00e1t tri\u1ec3n, bao g\u1ed3m m\u1ed9t m\u00f4 c\u1ea5y nh\u1ecf, r\u1eafn \u0111\u01b0\u1ee3c l\u00e0m t\u1eeb h\u1ed7n h\u1ee3p ethylene-vinyl axetat v\u00e0 d\u01b0\u1ee3c ch\u1ea5t. M\u1ed7i que c\u1ea5y ch\u1ee9a buprenorphine hydrochloride t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi 74,2mg buprenorphine.<\/p>\n\n\n\n<p>C\u1ea5u tr\u00fac thu \u0111\u01b0\u1ee3c l\u00e0 m\u1ed9t ch\u1ea5t n\u1ec1n r\u1eafn m\u00e0u tr\u1eafng \u0111\u1ebfn v\u00e0ng nh\u1ea1t, que c\u1ea5y h\u00ecnh que, d\u00e0i 26,5mm v\u00e0 \u0111\u01b0\u1eddng k\u00ednh 2,4mm, \u0111\u01b0\u1ee3c \u0111\u1eb7t d\u01b0\u1edbi da, th\u01b0\u1eddng l\u00e0 \u1edf c\u00e1nh tay tr\u00ean trong quy tr\u00ecnh t\u1ea1i ph\u00f2ng kh\u00e1m ngo\u1ea1i tr\u00fa v\u00e0 \u0111\u01b0\u1ee3c l\u1ea5y ra theo c\u00e1ch t\u01b0\u01a1ng t\u1ef1 v\u00e0o cu\u1ed1i giai \u0111o\u1ea1n \u0111i\u1ec1u tr\u1ecb. IXMO \u0111\u01b0\u1ee3c \u0111\u00f3ng g\u00f3i trong m\u1ed9t h\u1ed9p g\u1ed3m 4 b\u1ed9 ph\u1eadn c\u1ea5y gh\u00e9p.<\/p>\n\n\n\n<p>C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) \u0111\u00e3 ph\u00ea duy\u1ec7t Probuphine v\u00e0o th\u00e1ng 5 n\u0103m 2016 v\u00e0 \u0111\u00e2y l\u00e0 thi\u1ebft b\u1ecb c\u1ea5y gh\u00e9p buprenorphine \u0111\u1ea7u ti\u00ean v\u00e0 duy nh\u1ea5t c\u00f3 s\u1eb5n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb duy tr\u00ec ch\u1ee9ng nghi\u1ec7n ch\u1ea5t d\u1ea1ng thu\u1ed1c phi\u1ec7n \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u1ee7 \u0111i\u1ec1u ki\u1ec7n.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"403\" height=\"229\" src=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-6.png\" alt=\"\" class=\"wp-image-64042\" srcset=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-6.png 403w, https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-6-300x170.png 300w\" sizes=\"(max-width: 403px) 100vw, 403px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"389\" height=\"233\" src=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-7.png\" alt=\"\" class=\"wp-image-64043\" srcset=\"https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-7.png 389w, https:\/\/asprou.com\/wp-content\/uploads\/2022\/12\/image-7-300x180.png 300w\" sizes=\"(max-width: 389px) 100vw, 389px\" \/><\/figure>\n\n\n\n<p><strong>2. C\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng<\/strong><\/p>\n\n\n\n<p>Buprenorphine l\u00e0 opioid c\u00f3 t\u00e1c d\u1ee5ng d\u00e0i, c\u1ea1nh tranh t\u1ea1i th\u1ee5 th\u1ec3 Muy c\u1ee7a h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng, ho\u1ea1t t\u00ednh ch\u1ee7 v\u1eadn t\u1eebng ph\u1ea7n n\u00ean c\u00f3 t\u00e1c \u0111\u1ed9ng gi\u1ea3m \u0111au v\u00e0 c\u00e1c t\u00e1c d\u1ee5ng kh\u00e1c tr\u00ean th\u1ea7n kinh trung \u01b0\u01a1ng t\u01b0\u01a1ng t\u1ef1 nh\u01b0 Morphin v\u1edbi th\u1eddi gian gi\u1ea3m \u0111au th\u01b0\u1eddng d\u00e0i h\u01a1n Morphin, c\u00f3 th\u1ec3 g\u00e2y l\u1ec7 thu\u1ed9c thu\u1ed1c nh\u01b0ng t\u1ec9 l\u1ec7 th\u1ea5p h\u01a1n c\u00e1c ch\u1ea5t ch\u1ee7 v\u1eadn opioid nh\u01b0 Morphin.<\/p>\n\n\n\n<p><strong>3. Hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng<\/strong><\/p>\n\n\n\n<p><strong>3.1 Ch\u1ec9 \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb<\/strong><\/p>\n\n\n\n<p>Sixmo<sup>\u00ae<\/sup> \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb thay th\u1ebf t\u00ecnh tr\u1ea1ng l\u1ec7 thu\u1ed9c opioid \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n tr\u01b0\u1edfng th\u00e0nh \u1ed5n \u0111\u1ecbnh v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng, nh\u1eefng ng\u01b0\u1eddi c\u1ea7n kh\u00f4ng qu\u00e1 8 mg\/ng\u00e0y buprenorphine ng\u1eadm d\u01b0\u1edbi l\u01b0\u1ee1i.<\/p>\n\n\n\n<p><strong>3.2 Li\u1ec1u l\u01b0\u1ee3ng v\u00e0 c\u00e1ch d\u00f9ng<\/strong><\/p>\n\n\n\n<p>Vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ph\u1ea3i d\u01b0\u1edbi s\u1ef1 gi\u00e1m s\u00e1t c\u1ee7a chuy\u00ean gia ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe c\u00f3 kinh nghi\u1ec7m trong vi\u1ec7c qu\u1ea3n l\u00fd t\u00ecnh tr\u1ea1ng b\u1ec7nh nh\u00e2n l\u1ec7 thu\u1ed9c thu\u1ed1c.<\/p>\n\n\n\n<p>Vi\u1ec7c \u0111\u1eb7t v\u00e0 r\u00fat que c\u1ea5y ph\u1ea3i \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi m\u1ed9t b\u00e1c s\u0129 c\u00f3 chuy\u00ean m\u00f4n, m\u1ed7i \u0111\u1ee3t 4 que c\u1ea5y trong th\u1eddi gian s\u1eed d\u1ee5ng 6 th\u00e1ng.<\/p>\n\n\n\n<p>B\u1ec7nh nh\u00e2n tr\u01b0\u1edbc \u0111\u00e2y \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng buprenorphine ng\u1eadm d\u01b0\u1edbi l\u01b0\u1ee1i ho\u1eb7c d\u1ea1ng ph\u1ed1i h\u1edbp buprenorphine v\u00e0 naloxone ng\u1eadm d\u01b0\u1edbi l\u01b0\u1ee1i, ph\u1ea3i d\u00f9ng li\u1ec1u \u1ed5n \u0111\u1ecbnh t\u1eeb 2 \u0111\u1ebfn 8 mg\/ng\u00e0y trong \u00edt nh\u1ea5t 30 ng\u00e0y v\u00e0 \u0111\u01b0\u1ee3c chuy\u00ean gia ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe \u0111i\u1ec1u tr\u1ecb coi l\u00e0 \u1ed5n \u0111\u1ecbnh v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng.<\/p>\n\n\n\n<p><strong>3.3. Ti\u00eau ch\u00ed ng\u1eebng \u0111i\u1ec1u tr\u1ecb<\/strong><\/p>\n\n\n\n<p>B\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb n\u00ean xem x\u00e9t vi\u1ec7c lo\u1ea1i b\u1ecf c\u1ea5y gh\u00e9p n\u1ebfu:<\/p>\n\n\n\n<p>\u2022 B\u1ec7nh nh\u00e2n xu\u1ea5t hi\u1ec7n c\u00e1c d\u1ea5u hi\u1ec7u ng\u1ed9 \u0111\u1ed9c ho\u1eb7c qu\u00e1 li\u1ec1u (co \u0111\u1ed3ng t\u1eed, m\u00f4i t\u00edm t\u00e1i, an th\u1ea7n, nh\u1ecbp tim ch\u1eadm, h\u1ea1 huy\u1ebft \u00e1p, suy h\u00f4 h\u1ea5p).<\/p>\n\n\n\n<p>\u2022 B\u1ec7nh nh\u00e2n c\u1ea3m th\u1ea5y thi\u1ebfu hi\u1ec7u qu\u1ea3, b\u1eb1ng ch\u1ee9ng l\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng cai nghi\u1ec7n k\u00e9o d\u00e0i \u0111\u00f2i h\u1ecfi ph\u1ea3i \u0111i\u1ec1u tr\u1ecb l\u1eb7p l\u1ea1i b\u1eb1ng buprenorphine ng\u1eadm d\u01b0\u1edbi l\u01b0\u1ee1i.<\/p>\n\n\n\n<p><strong>3.4. T\u1ea7n su\u1ea5t s\u1eed d\u1ee5ng<\/strong><\/p>\n\n\n\n<ul><li>Nh\u1eefng b\u1ec7nh nh\u00e2n ng\u1eebng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Sixmo n\u00ean \u0111\u01b0\u1ee3c chuy\u1ec3n tr\u1edf l\u1ea1i li\u1ec1u buprenorphine ng\u1eadm d\u01b0\u1edbi l\u01b0\u1ee1i tr\u01b0\u1edbc \u0111\u00e2y c\u1ee7a h\u1ecd trong v\u00f2ng 12 \u0111\u1ebfn 24 gi\u1edd sau khi th\u00e1o thi\u1ebft b\u1ecb c\u1ea5y gh\u00e9p Sixmo (t\u1ee9c l\u00e0 li\u1ec1u m\u00e0 h\u1ecd \u0111\u00e3 \u0111\u01b0\u1ee3c chuy\u1ec3n tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Sixmo.<\/li><li>N\u1ebfu mu\u1ed1n ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb chu k\u1ef3 th\u1ee9 hai, c\u1ea7n lo\u1ea1i b\u1ecf c\u00e1c que c\u1ea5y c\u0169. Que c\u1ea5y m\u1edbi \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o m\u1eb7t trong c\u1ee7a c\u00e1nh tay \u0111\u1ed1i di\u1ec7n, x\u00e1c \u0111\u1ecbnh v\u1ecb tr\u00ed c\u1ea5y gh\u00e9p th\u00edch h\u1ee3p. Que c\u1ea5y gh\u00e9p \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb l\u1eb7p l\u1ea1i n\u00ean \u0111\u01b0\u1ee3c c\u1ea5y v\u00e0o d\u01b0\u1edbi da c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t sau khi th\u00e1o que c\u1ea5y c\u0169 tr\u01b0\u1edbc \u0111\u00f3, t\u1ed1t nh\u1ea5t l\u00e0 trong c\u00f9ng m\u1ed9t ng\u00e0y. N\u1ebfu vi\u1ec7c c\u1ea5y gh\u00e9p kh\u00f4ng di\u1ec5n ra trong ng\u00e0y, b\u1ec7nh nh\u00e2n c\u1ea7n \u0111\u01b0\u1ee3c duy tr\u00ec li\u1ec1u buprenorphine ng\u1eadm d\u01b0\u1edbi l\u01b0\u1ee1i c\u1ed1 \u0111\u1ecbnh t\u1eeb 2 \u0111\u1ebfn 8 mg\/ng\u00e0y, theo ch\u1ec9 \u0111\u1ecbnh l\u00e2m s\u00e0ng, cho \u0111\u1ebfn khi \u0111i\u1ec1u tr\u1ecb l\u1eb7p l\u1ea1i.<\/li><li>Buprenorphine ng\u1eadm d\u01b0\u1edbi l\u01b0\u1ee1i n\u00ean ng\u1eebng s\u1eed d\u1ee5ng t\u1eeb 12 \u0111\u1ebfn 24 gi\u1edd tr\u01b0\u1edbc khi \u0111\u1eb7t b\u1ed1n thi\u1ebft b\u1ecb c\u1ea5y gh\u00e9p Sixmo.<\/li><li>Sau m\u1ed9t l\u1ea7n ti\u00eam d\u01b0\u1edbi da \u1edf m\u1ed7i c\u00e1nh tay (t\u1ed5ng c\u1ed9ng l\u00e0 hai chu k\u1ef3 \u0111i\u1ec1u tr\u1ecb), h\u1ea7u h\u1ebft b\u1ec7nh nh\u00e2n n\u00ean \u0111\u01b0\u1ee3c chuy\u1ec3n tr\u1edf l\u1ea1i li\u1ec1u buprenorphine ng\u1eadm d\u01b0\u1edbi l\u01b0\u1ee1i tr\u01b0\u1edbc \u0111\u00e2y (t\u1ee9c l\u00e0 li\u1ec1u m\u00e0 h\u1ecd \u0111\u01b0\u1ee3c chuy\u1ec3n sang \u0111i\u1ec1u tr\u1ecb Sixmo) \u0111\u1ec3 ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb.<\/li><li>Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u tri\u1ec3n v\u1ecdng n\u00e0o v\u1edbi Sixmo sau hai chu k\u1ef3 \u0111i\u1ec1u tr\u1ecb v\u00e0 kh\u00f4ng c\u00f3 kinh nghi\u1ec7m v\u1ec1 vi\u1ec7c c\u1ea5y gh\u00e9p Sixmo v\u00e0o c\u00e1c v\u1ecb tr\u00ed kh\u00e1c c\u1ee7a c\u00e1nh tay, c\u00e1c v\u1ecb tr\u00ed kh\u00e1c ngo\u00e0i c\u00e1nh tay tr\u00ean ho\u1eb7c c\u1ea5y gh\u00e9p l\u1ea1i v\u00e0o c\u00e1c v\u1ecb tr\u00ed \u0111\u00e3 s\u1eed d\u1ee5ng tr\u01b0\u1edbc \u0111\u00f3.<\/li><\/ul>\n\n\n\n<p><strong>3.5. L\u00e2m s\u00e0ng tr\u00ean \u0111\u1ed1i t\u01b0\u1ee3ng \u0111\u1eb7c bi\u1ec7t<\/strong><\/p>\n\n\n\n<ul><li><strong>Ng\u01b0\u1eddi gi\u00e0<\/strong><\/li><\/ul>\n\n\n\n<p>C\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng v\u1ec1 Sixmo kh\u00f4ng bao g\u1ed3m c\u00e1c b\u1ec7nh nh\u00e2n tr\u00ean 65 tu\u1ed5i v\u00e0 do \u0111\u00f3, vi\u1ec7c s\u1eed d\u1ee5ng s\u1ea3n ph\u1ea9m cho nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng n\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o. Hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n c\u1ee7a buprenorphine \u1edf b\u1ec7nh nh\u00e2n cao tu\u1ed5i &gt; 65 tu\u1ed5i ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp.<\/p>\n\n\n\n<ul><li><strong>Suy gan<\/strong><\/li><\/ul>\n\n\n\n<p>Do kh\u00f4ng th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh n\u1ed3ng \u0111\u1ed9 buprenorphine trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb Sixmo n\u00ean Sixmo ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh \u1edf b\u1ec7nh nh\u00e2n suy gan n\u1eb7ng.<\/p>\n\n\n\n<p>B\u1ec7nh nh\u00e2n suy gan nh\u1eb9 \u0111\u1ebfn trung b\u00ecnh n\u00ean \u0111\u01b0\u1ee3c theo d\u00f5i c\u00e1c d\u1ea5u hi\u1ec7u v\u00e0 tri\u1ec7u ch\u1ee9ng ng\u1ed9 \u0111\u1ed9c ho\u1eb7c qu\u00e1 li\u1ec1u do t\u0103ng n\u1ed3ng \u0111\u1ed9 buprenorphine v\u1edbi c\u00e1c tri\u1ec7u ch\u1ee9ng: t\u00edm m\u00f4i, l\u01a1 m\u01a1, nh\u1ecbp tim ch\u1eadm, h\u1ea1 huy\u1ebft \u00e1p, suy h\u00f4 h\u1ea5p. Trong tr\u01b0\u1eddng h\u1ee3p quan s\u00e1t th\u1ea5y c\u00e1c tri\u1ec7u ch\u1ee9ng ng\u1ed9 \u0111\u1ed9c ho\u1eb7c qu\u00e1 li\u1ec1u, lo\u1ea1i b\u1ecf que c\u1ea5y l\u00e0 \u0111i\u1ec1u b\u1eaft bu\u1ed9c.<\/p>\n\n\n\n<ul><li><strong>Suy th\u1eadn<\/strong><\/li><\/ul>\n\n\n\n<p>S\u1ef1 \u0111\u00e0o th\u1ea3i qua th\u1eadn \u0111\u00f3ng m\u1ed9t vai tr\u00f2 t\u01b0\u01a1ng \u0111\u1ed1i nh\u1ecf (kho\u1ea3ng 30%) trong t\u1ed5ng \u0111\u1ed9 thanh th\u1ea3i c\u1ee7a buprenorphine v\u00e0 n\u1ed3ng \u0111\u1ed9 buprenorphine trong huy\u1ebft t\u01b0\u01a1ng kh\u00f4ng t\u0103ng \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn.<\/p>\n\n\n\n<p>Kh\u00f4ng c\u1ea7n \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u Sixmo \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn. N\u00ean th\u1eadn tr\u1ecdng khi d\u00f9ng thu\u1ed1c cho b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng (\u0111\u1ed9 thanh th\u1ea3i creatinine &lt; 30 mL\/ph\u00fat).<\/p>\n\n\n\n<ul><li><strong>Tr\u1ebb em<\/strong><\/li><\/ul>\n\n\n\n<p>T\u00ednh an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a Sixmo \u1edf tr\u1ebb em d\u01b0\u1edbi 18 tu\u1ed5i v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp. Kh\u00f4ng c\u00f3 d\u1eef li\u1ec7u c\u00f3 s\u1eb5n.<\/p>\n\n\n\n<p><strong>4. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh<\/strong><\/p>\n\n\n\n<p>B\u1ec7nh nh\u00e2n m\u1eabn c\u1ea3m v\u1edbi b\u1ea5t c\u1ee9 th\u00e0nh ph\u1ea7n n\u00e0o c\u1ee7a thu\u1ed1c.<\/p>\n\n\n\n<p>B\u1ec7nh nh\u00e2n \u0111ang trong t\u00ecnh tr\u1ea1ng suy gi\u1ea3m ch\u1ee9c n\u0103ng h\u00f4 h\u1ea5p m\u1ee9c \u0111\u1ed9 n\u1eb7ng, suy gi\u1ea3m ch\u1ee9c n\u0103ng gan m\u1ee9c \u0111\u1ed9 n\u1eb7ng.<\/p>\n\n\n\n<p>B\u1ec7nh nh\u00e2n b\u1ecb m\u00ea s\u1ea3ng, b\u1ec7nh nh\u00e2n nghi\u1ec7n r\u01b0\u1ee3u c\u1ea5p t\u00ednh.<\/p>\n\n\n\n<p>B\u1ec7nh nh\u00e2n \u0111ang s\u1eed d\u1ee5ng thu\u1ed1c \u1ee9c ch\u1ebf men MAO ho\u1eb7c trong v\u00f2ng 2 tu\u1ea7n \u0111\u00e3 s\u1eed d\u1ee5ng IMAO.<\/p>\n\n\n\n<p>B\u1ec7nh nh\u00e2n l\u00e0 ph\u1ee5 n\u1eef \u0111ang mang thai, ph\u1ee5 n\u1eef \u0111ang trong th\u1eddi gian nu\u00f4i con b\u00fa.<\/p>\n\n\n\n<p><strong>5. T\u00e1c d\u1ee5ng ph\u1ee5<\/strong><\/p>\n\n\n\n<ul><li>Nhi\u1ec5m tr\u00f9ng t\u1ea1i v\u1ecb tr\u00ed c\u1ea5y que. B\u1ec7nh nh\u00e2n kh\u00f4ng t\u1ef1 m\u00ecnh g\u1ee1 b\u1ecf Probuphine .<\/li><li>N\u1ebfu Probuphine r\u01a1i ra kh\u1ecfi c\u00e1nh tay ho\u1eb7c n\u1ebfu b\u1ec7nh nh\u00e2n ng\u1eebng \u0111i\u1ec1u tr\u1ecb, c\u00f3 th\u1ec3 c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng run, \u0111\u1ed5 m\u1ed3 h\u00f4i nhi\u1ec1u h\u01a1n b\u00ecnh th\u01b0\u1eddng, c\u1ea3m th\u1ea5y n\u00f3ng ho\u1eb7c l\u1ea1nh h\u01a1n b\u00ecnh th\u01b0\u1eddng, ch\u1ea3y n\u01b0\u1edbc m\u0169i, ch\u1ea3y n\u01b0\u1edbc m\u1eaft, n\u1ed5i da g\u00e0, ti\u00eau ch\u1ea3y, n\u00f4n m\u1eeda v\u00e0 \u0111au c\u01a1. \u0110\u00f3 c\u00f3 th\u1ec3 l\u00e0 h\u1ed9i ch\u1ee9ng thi\u1ebfu thu\u1ed1c, c\u1ea7n b\u00e1o ngay cho b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb.<\/li><li>M\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 th\u01b0\u1eddng g\u1eafp: v\u00e0ng da, v\u00e0ng m\u1eaft, kh\u00f4 mi\u1ec7ng, t\u00e1o b\u00f3, b\u00ed ti\u1ec3u, ph\u00e1t ban, n\u1ed5i m\u1ec1 \u0111ay, s\u01b0ng m\u1eb7t, th\u1edf kh\u00f2 kh\u00e8 ho\u1eb7c ch\u00f3ng m\u1eaft, m\u1ea5t \u00fd th\u1ee9c, t\u1ee5t huy\u1ebft \u00e1p t\u01b0 th\u1ebf.<\/li><\/ul>\n\n\n\n<p><strong>T\u00c0I LI\u1ec6U THAM KH\u1ea2O<\/strong><\/p>\n\n\n\n<ol type=\"1\"><li>http:\/\/<a href=\"https:\/\/www.vidal.fr\/actualites\/29851-dependance-aux-opioides-sixmo-buprenorphine-en-implant-\">vidal.fr\/actualites\/29851-dependance-aux-opioides-sixmo-buprenorphine-en-implant-<\/a>sous-cutane-de-longue-duree-d-39-action.html<\/li><li>http:\/\/<a href=\"https:\/\/www.titanpharm.com\/news\/press-releases\/detail\/212\/titan-pharmaceuticals-and-molteni-announce-positive-eu-chmp\">Titan Pharmaceuticals And Molteni Announce Positive EU CHMP Opinion For Probuphine: Titan Pharmaceuticals, Inc. (TTNP)<\/a><\/li><li>Strang J, Volkow ND, Degenhardt L, et al. Opioid use disorder. Nat Rev Dis Primers. 2020;6(1):3.<\/li><li>Bell J, Strang J. Medication treatment of opioid use disorder. Biol Psychiatry. 2020;87(1):82\u201388. doi:10.1016\/j.biopsych.2019. 06.020<\/li><li>Sordo L, Barrio G, Bravo MJ, et al. Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies. BMJ. 2017;357:j1550. doi:10.1136\/bmj.j1550<\/li><\/ol>\n\n\n\n<p><strong>ThS.DS. Nguy\u1ec5n H\u1eefu Ph\u00fac<\/strong><\/p>\n\n\n\n<p>B\u1ed9 m\u00f4n H\u00f3a D\u01b0\u1ee3c &#8211; H\u00f3a h\u1eefu c\u01a1 &#8211; H\u00f3a h\u1ecdc<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Buprenorphine l\u00e0 ho\u1ea1t ch\u1ea5t \u0111ang \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ng\u00e0y c\u00e0ng r\u1ed9ng r\u00e3i trong c\u00e1c ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb l\u00e0m gi\u1ea3m c\u01a1n \u0111au li\u00ean t\u1ee5c v\u00e0 nghi\u00eam tr\u1ecdng (ch\u1eb3ng h\u1ea1n nh\u01b0 [&hellip;]<\/p>\n","protected":false},"author":82,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":""},"categories":[1796,267,2267],"tags":[],"yoast_head":"\n<title>SIXMO\u00ae, QUE C\u1ea4Y GH\u00c9P D\u01af\u1edaI DA T\u00c1C D\u1ee4NG K\u00c9O D\u00c0I BUPRENORPHINE - Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Qu\u1ed1c t\u1ebf H\u1ed3ng B\u00e0ng<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/asprou.com\/khoa-duoc\/sixmo-que-cay-ghep-duoi-da-tac-dung-keo-dai-buprenorphine\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SIXMO\u00ae, QUE C\u1ea4Y GH\u00c9P D\u01af\u1edaI DA T\u00c1C D\u1ee4NG K\u00c9O D\u00c0I BUPRENORPHINE - 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