{"id":62307,"date":"2022-09-06T08:41:45","date_gmt":"2022-09-06T01:41:45","guid":{"rendered":"https:\/\/asprou.com\/?p=62307"},"modified":"2023-04-06T15:46:48","modified_gmt":"2023-04-06T08:46:48","slug":"cong-nghe-in-3d-va-mot-so-ung-dung-trong-nghien-cuu-thuoc","status":"publish","type":"post","link":"https:\/\/asprou.com\/khoa-duoc\/tin-tuc-khoa-duoc\/cong-nghe-in-3d-va-mot-so-ung-dung-trong-nghien-cuu-thuoc\/","title":{"rendered":"C\u00d4NG NGH\u1ec6 IN 3D V\u00c0 M\u1ed8T S\u1ed0 \u1ee8NG D\u1ee4NG TRONG NGHI\u00caN C\u1ee8U THU\u1ed0C"},"content":{"rendered":"\n

Gi\u1edbi thi\u1ec7u v\u1ec1 c\u00f4ng ngh\u1ec7 in 3D<\/span><\/strong><\/p>\n\n\n\n

Hi\u1ec7n nay, kh\u00e1i ni\u1ec7m \u201cin 3D\u201d(3D printing) \u0111\u00e3 tr\u1edf n\u00ean quen thu\u1ed9c trong nhi\u1ec1u l\u0129nh v\u1ef1c s\u1ea3n xu\u1ea5t. C\u1ee5m t\u1eeb n\u00e0y c\u00f2n \u0111\u1ed3ng ngh\u0129a v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi m\u1ed9t s\u1ed1 c\u1ee5m t\u1eeb ph\u1ed5 bi\u1ebfn nh\u01b0 \u201cin nguy\u00ean m\u1eabu nhanh ch\u00f3ng\u201d (rapid prototyping),\u201ct\u1ea1o v\u1eadt th\u1ec3 r\u1eafn \u0111\u1ecbnh d\u1ea1ng t\u1ef1 do\u201d (solid free form fabrication) hay \u201cch\u1ebf t\u1ea1o b\u1eb1ng c\u00e1ch b\u1ed3i \u0111\u1eafp\u201d(additive manufacturing) [1].<\/p>\n\n\n\n

\u201cIn 3D\u201d \u0111\u01b0\u1ee3c ph\u00e1t minh v\u00e0o nh\u1eefng n\u0103m 1980 v\u00e0 m\u00e1y in 3D \u0111\u1ea7u ti\u00ean \u0111i v\u00e0o ho\u1ea1t \u0111\u1ed9ng n\u0103m 1986 \u0111\u00e3 thi\u1ebft l\u1eadp \u0111\u01b0\u1ee3c n\u1ec1n t\u1ea3ng v\u1eefng ch\u1eafc cho c\u00f4ng ngh\u1ec7 m\u1edbi n\u00e0y. \u1ee8ng d\u1ee5ng \u0111\u1ea7u ti\u00ean c\u1ee7a in 3D trong y t\u1ebf l\u00e0 vi\u1ec7c th\u1eed nghi\u1ec7m t\u00e1i t\u1ea1o \u0111\u1ea7u v\u00e0 c\u1ed5 \u0111\u00e3 l\u00e0m thay \u0111\u1ed5i m\u1ed9t s\u1ed1 k\u1ef9 thu\u1eadt c\u1ea5y gh\u00e9p h\u1ed9p s\u1ecd v\u00e0o gi\u1eefa nh\u1eefng n\u0103m 1990 [2]. Trong 20 n\u0103m \u0111\u1ea7u ti\u00ean, c\u00f4ng ngh\u1ec7 in 3D ch\u1ec9 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng th\u00e0nh t\u1ef1u nh\u1ecf. Tuy nhi\u00ean, \u0111\u1ebfn sau n\u0103m 2009, nhi\u1ec1u b\u1eb1ng s\u00e1ng ch\u1ebf v\u1ec1 in 3D h\u1ebft h\u1ea1n b\u1ea3o v\u1ec7 b\u1ea3n quy\u1ec1n. L\u0129nh v\u1ef1c n\u00e0y l\u1eadp t\u1ee9c thu h\u00fat nhi\u1ec1u nh\u00e0 s\u1ea3n xu\u1ea5t tham gia nghi\u00ean c\u1ee9u v\u00e0 \u0111\u1ea7u t\u01b0, t\u1ea1o ra s\u1ef1 bi\u1ebfn \u0111\u1ed9ng l\u1edbn tr\u00ean th\u1ecb tr\u01b0\u1eddng v\u00e0 l\u00e0m gi\u1ea3m gi\u00e1 th\u00e0nh s\u1ea3n xu\u1ea5t. T\u1eeb \u0111\u00f3, in 3D tr\u1edf th\u00e0nh m\u1ed9t trong nh\u1eefng ch\u00eca kh\u00f3a c\u00f4ng ngh\u1ec7 t\u1ea1o c\u01a1 h\u1ed9i cho nh\u1eefng s\u00e1ng ch\u1ebf m\u1edbi ra \u0111\u1eddi, m\u1edf ra m\u1ed9t th\u1eddi k\u1ef3 ph\u00e1t tri\u1ec3n m\u1ea1nh m\u1ebd c\u1ee7a ng\u00e0nh c\u00f4ng nghi\u1ec7p n\u00e0y trong r\u1ea5t nhi\u1ec1u l\u0129nh v\u1ef1c c\u1ee7a \u0111\u1eddi s\u1ed1ng, \u0111\u1eb7c bi\u1ec7t l\u00e0 y t\u1ebf. Vi\u1ec7c ch\u1ebf t\u1ea1o c\u00e1c b\u1ed9 ph\u1eadn c\u01a1 th\u1ec3 hay m\u00f4 nh\u00e2n t\u1ea1o \u0111\u1ec3 c\u1ea5y gh\u00e9p v\u00e0 ph\u1ee5c h\u00ecnh b\u1eb1ng c\u00e1ch in 3D \u0111\u00e3 th\u1ef1c s\u1ef1 l\u00e0m n\u00ean cu\u1ed9c c\u00e1ch m\u1ea1ng trong l\u0129nh v\u1ef1c y -sinh. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u th\u00e0nh c\u00f4ng trong ph\u1eabu thu\u1eadt, \u0111i\u1ec1u tr\u1ecb b\u1ecfng, gh\u00e9p m\u1ea1ch m\u00e1u v\u00e0 m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p kh\u00e1c [3], [2], [4].<\/p>\n\n\n\n

Trong c\u00f4ng ngh\u1ec7 d\u01b0\u1ee3c ph\u1ea9m, nghi\u00ean c\u1ee9u v\u1ec1 thu\u1ed1c in 3D l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 v\u00e0o n\u0103m 1996 gi\u1edbi thi\u1ec7u m\u1ed9t y\u1ebfu t\u1ed1 m\u1edbi trong s\u1ea3n xu\u1ea5t \u0111\u00f3 l\u00e0 \u1ee9ng d\u1ee5ng k\u1ef9 thu\u1eadt s\u1ed1 \u0111\u1ec3 k\u1ebft h\u1ee3p v\u00e0 s\u1eafp x\u1ebfp c\u00e1c th\u00e0nh ph\u1ea7n trong d\u1ea1ng b\u00e0o ch\u1ebf. \u0110\u00e2y l\u00e0 b\u01b0\u1edbc ti\u1ebfn quan tr\u1ecdng trong nghi\u00ean c\u1ee9u ph\u00e1t tri\u1ec3n thu\u1ed1c, c\u00f3 th\u1ec3 t\u1ea1o ra nh\u1eefng t\u00e1c \u0111\u1ed9ng t\u00edch c\u1ef1c v\u00e0o qu\u00e1 tr\u00ecnh gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t kh\u1ecfi thu\u1ed1c. So v\u1edbi c\u00e1c k\u1ef9 thu\u1eadt truy\u1ec1n th\u1ed1ng,s\u1ef1 kh\u00e1c bi\u1ec7t c\u1ee7a c\u00f4ng ngh\u1ec7 in 3D l\u00e0 c\u00f3 ti\u1ec1m n\u0103ng t\u1ea1o ra c\u00e1c s\u1ea3n ph\u1ea9m ph\u1ee9c t\u1ea1p, c\u00e1 th\u1ec3 h\u00f3a v\u00e0 s\u1ea3n xu\u1ea5t theo y\u00eau c\u1ea7u. C\u00e1c ch\u1ebf ph\u1ea9m ph\u1ee9c t\u1ea1p c\u00f3 th\u1ec3 k\u1ebft h\u1ee3p t\u1ed1i \u01b0u nhi\u1ec1u th\u00e0nh ph\u1ea7n, thay \u0111\u1ed5i c\u01a1 ch\u1ebf ho\u1eb7c c\u00e1ch th\u1ee9c gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t. Nh\u1eefng ch\u1ebf ph\u1ea9m \u0111\u01b0\u1ee3c c\u00e1 th\u1ec3 h\u00f3a c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n v\u00e0 \u0111\u01a1n gi\u1ea3n h\u00f3a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb, \u0111\u1eb7c bi\u1ec7t th\u00edch h\u1ee3p v\u1edbi tr\u1ebb em v\u00e0 ng\u01b0\u1eddi gi\u00e0. Nh\u1eefng ch\u1ebf ph\u1ea9m s\u1ea3n xu\u1ea5t theo y\u00eau c\u1ea7u m\u1edf r\u1ed9ng c\u01a1 h\u1ed9i s\u1eed d\u1ee5ng cho c\u00e1c lo\u1ea1i thu\u1ed1c m\u1edbi, c\u00e1c thu\u1ed1c c\u1ea5p c\u1ee9u v\u00e0 c\u00e1c thu\u1ed1c c\u00f3 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh k\u00e9m. C\u00e1c s\u1ea3n ph\u1ea9m n\u00e0y l\u00e0m thay \u0111\u1ed5i t\u01b0\u01a1ng t\u00e1c thu\u1ed1c v\u00e0 b\u1ec7nh nh\u00e2n, t\u1eeb \u0111\u00f3 c\u1ea3i thi\u1ec7n s\u1ef1 tu\u00e2n th\u1ee7 v\u00e0 t\u0103ng hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a thu\u1ed1c [4].<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

\u1ee8ng d\u1ee5ng c\u00f4ng ngh\u1ec7 in 3D trong nghi\u00ean c\u1ee9u, s\u1ea3n xu\u1ea5t thu\u1ed1c<\/span><\/strong><\/p>\n\n\n\n

B\u00e0o ch\u1ebf vi\u00ean gi\u1ea3i ph\u00f3ng nhanh (fast release)<\/strong>
<\/span>Ng\u00e0y 3 th\u00e1ng 8 n\u0103m 2015, C\u1ee5c qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m M\u1ef9 \u0111\u00e3 ph\u00ea chu\u1ea9n thu\u1ed1c Spritam c\u1ee7a c\u00f4ng ty d\u01b0\u1ee3c Aprecia. S\u1ea3n ph\u1ea9m n\u00e0y hi\u1ec7n \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i \u0111\u1ec3 ch\u1ed1ng \u0111\u1ed9ng kinh. Spritam \u0111\u01b0\u1ee3c in 3D b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p \u0111\u00f4ng r\u1eafn b\u1ed9t b\u1eb1ng t\u00e1 d\u01b0\u1ee3c d\u00ednh l\u1ecfng (DOS). Vi\u00ean thu\u1ed1c h\u00f2a tan g\u1ea7n nh\u01b0 ngay l\u1eadp t\u1ee9c khi th\u1ea3 v\u00e0o n\u01b0\u1edbc, th\u00edch h\u1ee3p v\u1edbi nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb ch\u1ee9ng kh\u00f3 nu\u1ed1t, hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y th\u01b0\u1eddng g\u1eb7p \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u1ed9ng kinh.
Fina F. v\u00e0 c\u1ed9ng s\u1ef1 nghi\u00ean c\u1ee9u b\u00e0o ch\u1ebf vi\u00ean n\u00e9n paracetamol r\u00e3 nhanh trong mi\u1ec7ng b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p SLS (selective laser sintering \u2013 H\u00f3a l\u1ecfng ch\u1ea5t r\u1eafn b\u1eb1ng tia laser ch\u1ecdn l\u1ecdc) v\u1edbi c\u00e1c t\u00e1 d\u01b0\u1ee3c hydroxypropylmethyl cellulose (HPMC), methyl cellulose (MC), vinylpyrolidon-vinyl acetat copolyme (Kolidon VA64). Vi\u00ean thu\u1ed1c r\u00e3 trong v\u00f2ng 4 gi\u00e2y v\u00e0 h\u00f2a tan h\u01a1n 90 % sau 5 ph\u00fat [5].<\/p>\n\n\n\n

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H\u00ecnh 1. Vi\u00ean in v\u1edbi t\u00e1 d\u01b0\u1ee3c HPMC v\u00e0 Kollidon\u00ae<\/em><\/strong><\/figcaption><\/figure><\/div>\n\n\n\n

Ehtezazi T. v\u00e0 c\u1ed9ng s\u1ef1 nghi\u00ean c\u1ee9u b\u00e0o ch\u1ebf m\u00e0ng phim tan nhanh trong mi\u1ec7ng ch\u1ee9a d\u01b0\u1ee3c ch\u1ea5t paracetamol v\u00e0 ibuprofen v\u1edbi c\u00e1c t\u00e1 d\u01b0\u1ee3c polyethylen oxid (PEO) v\u00e0 alcol polyvinic (PVA) b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p \u0111\u00f9n n\u00f3ng ch\u1ea3y. M\u00e0ng 1 l\u1edbp c\u00f3 \u0111\u1ed9 d\u00e0y 197 \u00b1 21 \u03bcm v\u00e0 h\u00f2a tan sau 42 \u00b1 7 gi\u00e2y. M\u00e0ng 2 l\u1edbp c\u00f3 \u0111\u1ed9 d\u00e0y 298 \u00b1 15 \u03bcm v\u00e0 h\u00f2a tan sau 48 \u00b1 5 gi\u00e2y [4].<\/p>\n\n\n\n

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H\u00ecnh 2. \u1ea2nh ch\u1ee5p phim \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb c\u00e1c c\u00f4ng th\u1ee9c v\u00e0 h\u00ecnh \u1ea3nh ch\u1ee5p SEM t\u01b0\u01a1ng \u1ee9ng<\/em><\/strong><\/figcaption><\/figure><\/div>\n\n\n\n

Jamro\u0301z W. v\u00e0 c\u1ed9ng s\u1ef1 nghi\u00ean c\u1ee9u b\u00e0o ch\u1ebf m\u00e0ng h\u00f2a tan trong mi\u1ec7ng ch\u1ee9a aripirazol v\u00e0 PVA b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p \u0111\u00f9n n\u00f3ng ch\u1ea3y. Do d\u01b0\u1ee3c ch\u1ea5t chuy\u1ec3n sang d\u1ea1ng v\u00f4 \u0111\u1ecbnh h\u00ecnh sau qu\u00e1 tr\u00ecnh \u0111\u00f9n n\u00ean t\u1ed1c \u0111\u1ed9 ho\u00e0 tan d\u01b0\u1ee3c ch\u1ea5t t\u1eeb d\u1ea1ng thu\u1ed1c t\u0103ng \u0111\u00e1ng k\u1ec3, aripiraziol h\u00f2a tan tr\u00ean 90 % sau 15 ph\u00fat [6].<\/p>\n\n\n\n

B\u00e0o ch\u1ebf vi\u00ean gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i<\/strong>
<\/span>Vi\u00ean d\u1ea1ng c\u1ed1t ch\u1ee9a s\u00e1p ong v\u00e0 fenofibrat \u0111\u00e3 \u0111\u01b0\u1ee3c Kyobula b\u00e0o ch\u1ebf b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p DOD v\u1edbi c\u1ea5u tr\u00fac t\u1ed5 ong v\u00e0 d\u01b0\u1ee3c ch\u1ea5t l\u1ea5p \u0111\u1ea7y c\u00e1c khoang r\u1ed7ng. S\u1ea3n ph\u1ea9m nghi\u00ean c\u1ee9u gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t k\u00e9o d\u00e0i \u0111\u1ebfn 12 gi\u1edd. \u0110\u1ed3 th\u1ecb gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t ch\u1ec9 ra r\u1eb1ng, \u0111\u01b0\u1eddng k\u00ednh c\u00e1c khoang r\u1ed7ng t\u1ed5 ong v\u00e0 t\u00ednh th\u1ea5m c\u1ee7a v\u1eadt li\u1ec7u \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ed1c \u0111\u1ed9 v\u00e0 m\u1ee9c \u0111\u1ed9 h\u00f2a tan d\u01b0\u1ee3c ch\u1ea5t t\u1eeb d\u1ea1ng thu\u1ed1c [7]. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y, c\u00f3 th\u1ec3 s\u1ea3n xu\u1ea5t c\u00e1c lo\u1ea1i thu\u1ed1c c\u00e1 th\u1ec3 h\u00f3a khi s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p v\u1edbi c\u00e1c v\u1eadt li\u1ec7u kh\u00e1c nhau c\u00f3 h\u00ecnh d\u1ea1ng kh\u00e1c nhau.<\/p>\n\n\n\n

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H\u00ecnh 3. \u1ea2nh ch\u1ee5p vi\u00ean n\u00e9n r\u1eafn h\u00ecnh t\u1ed5 ong \u0111\u01b0\u1ee3c in v\u1edbi c\u00e1c k\u00edch th\u01b0\u1edbc \u00f4 kh\u00e1c nhau t\u1eeb 0,20 mm \u0111\u1ebfn 1,83 mm v\u00e0 \u1ea3nh qu\u00e9t\/c\u1eaft 3D<\/em><\/strong><\/figcaption><\/figure><\/div>\n\n\n\n

Chai X. v\u00e0 c\u1ed9ng s\u1ef1 nghi\u00ean c\u1ee9u b\u00e0o ch\u1ebf vi\u00ean n\u1ed5i gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i domperidon b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p \u0111\u00f9n n\u00f3ng ch\u1ea3y v\u1edbi c\u00e1c t\u00e1 d\u01b0\u1ee3c hydroxypropyl cellulose v\u00e0 bari sulfat. Vi\u00ean nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 sinh kh\u1ea3 d\u1ee5ng tr\u00ean th\u1ecf, k\u1ebft qu\u1ea3 cho th\u1ea5y vi\u00ean thu\u1ed1c c\u00f3 th\u1ec3 n\u1ed5i trong d\u1ea1 d\u00e0y kho\u1ea3ng 10 gi\u1edd, Tmax k\u00e9o d\u00e0i g\u1ea5p 3 l\u1ea7n v\u00e0 n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u cao g\u1ea5p \u0111\u00f4i so v\u1edbi vi\u00ean tr\u00ean th\u1ecb tr\u01b0\u1eddng [8].<\/p>\n\n\n\n

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H\u00ecnh 4. \u1ea2nh ch\u1ee5p vi\u00ean n\u00e9n DOM-FSR n\u1ed5i trong m\u00f4i tr\u01b0\u1eddng h\u00f2a tan (dung d\u1ecbch HCl 0,1 N) \u1edf 37 \u00b1 0,5 \u00b0 C. (A) t = 1 h, (B) t = 2 h, (C) t = 4 h v\u00e0 (D) t = 8 h.<\/em><\/strong><\/figcaption><\/figure><\/div>\n\n\n\n

Clark E. v\u00e0 c\u1ed9ng s\u1ef1 \u0111\u00e3 nghi\u00ean c\u1ee9u kh\u1ea3 n\u0103ng \u1ee9ng d\u1ee5ng polyme quang h\u00f3a trong s\u1ea3n xu\u1ea5t thu\u1ed1c b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p in l\u1eadp th\u1ec3, vi\u00ean thu\u1ed1c ch\u1ee9a ropinirol hydroclorid, polyethylen glycol diacrylat (PEGDA) v\u00e0 Irgacure 2959 \u0111\u01b0\u1ee3c b\u00e0o ch\u1ebf trong m\u00f4i tr\u01b0\u1eddng c\u00f3 h\u00e0m l\u01b0\u1ee3ng oxy th\u1ea5p. Li\u00ean k\u1ebft ngang c\u1ee7a c\u00e1c polyme nh\u1ea1y c\u1ea3m v\u1edbi tia c\u1ef1c t\u00edm t\u1ea1o ra ropinirol hydroclorid v\u00f4 \u0111\u1ecbnh h\u00ecnh ph\u00e2n t\u00e1n trong polyme. D\u01b0\u1ee3c ch\u1ea5t gi\u1ea3i ph\u00f3ng li\u00ean t\u1ee5c t\u1eeb d\u1ea1ng thu\u1ed1c trong v\u00f2ng 6 gi\u1edd. Th\u1eed nghi\u1ec7m cho th\u1ea5y, c\u00e1c v\u1eadt li\u1ec7u t\u1ea1o c\u1ed1t gi\u1ea3i ph\u00f3ng k\u00e9o d\u00e0i \u0111\u00e3 s\u1eed d\u1ee5ng ph\u00f9 h\u1ee3p v\u1edbi ph\u01b0\u01a1ng ph\u00e1p in l\u1eadp th\u1ec3 [9].<\/p>\n\n\n\n

\"\"
H\u00ecnh 5. H\u00ecnh \u1ea3nh vi\u00ean n\u00e9n in ropinirole HCl. a, d) H\u00ecnh \u1ea3nh vi\u00ean c\u00f3 115 l\u1edbp<\/strong><\/em><\/figcaption><\/figure><\/div>\n\n\n\n

Okwuosa T. C., v\u00e0 c\u1ed9ng s\u1ef1 b\u00e0o ch\u1ebf vi\u00ean theophylin gi\u1ea3i ph\u00f3ng ch\u1eadm v\u1edbi c\u01a1 ch\u1ebf kh\u00e1ng d\u1ecbch v\u1ecb d\u1ea1 d\u00e0y b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p \u0111\u00f9n n\u00f3ng ch\u1ea3y. C\u00e1c t\u00e1 d\u01b0\u1ee3c s\u1eed d\u1ee5ng trong nghi\u00ean c\u1ee9u bao g\u1ed3m: PVP 110, Eudragit L100. S\u1ea3n ph\u1ea9m nghi\u00ean c\u1ee9u c\u00f3 c\u1ea5u tr\u00fac nh\u00e2n-v\u1ecf, do l\u1edbp v\u1ecf ch\u1eafc ch\u1eafn v\u00e0 kh\u00f4ng c\u00f3 khi\u1ebfm khuy\u1ebft n\u00ean s\u1ea3n ph\u1ea9m kh\u00e1ng acid d\u1ecbch v\u1ecb r\u1ea5t t\u1ed1t [10].<\/p>\n\n\n\n

\"\"
H\u00ecnh 6. H\u00ecnh \u1ea3nh m\u00f4 ph\u1ecfng (Autodesk 3DS Max) c\u1ee7a c\u00e1c thi\u1ebft k\u1ebf l\u00f5i v\u1ecf v\u1edbi \u0111\u1ed9 d\u00e0y v\u1ecf t\u0103ng d\u1ea7n (0,17, 0,35, 0,52, 0,70 v\u00e0 0,87 mm). (c) H\u00ecnh \u1ea3nh v\u1ec1 thi\u1ebft k\u1ebf l\u00f5i v\u1ecf \u0111\u00e3 ho\u00e0n th\u00e0nh 30% v\u1edbi l\u00f5i theophylline v\u00e0 \u0111\u1ed9 d\u00e0y v\u1ecf Eudragit L100-55 t\u0103ng d\u1ea7n. (d) \u1ea2nh SEM c\u1ee7a b\u1ec1 m\u1eb7t vi\u00ean n\u00e9n. (e) T\u00e1c \u0111\u1ed9ng c\u1ee7a \u0111\u1ed9 d\u00e0y l\u1edbp v\u1ecf c\u1ee7a in 3D \u0111\u1ed1i v\u1edbi d\u1ea1ng ph\u00f3ng th\u00edch in vitro c\u1ee7a theophylline t\u1eeb vi\u00ean n\u00e9n in 3D trong th\u1eed nghi\u1ec7m h\u00f2a tan thay \u0111\u1ed5i \u0111\u1ed9 pH c\u1ee7a USP II.<\/strong><\/em><\/figcaption><\/figure><\/div>\n\n\n\n

K\u1ebft lu\u1eadn<\/strong>
<\/span>C\u00f4ng ngh\u1ec7 in 3D \u1ee9ng d\u1ee5ng trong ch\u1ea9n \u0111o\u00e1n, \u0111i\u1ec1u tr\u1ecb v\u00e0 s\u1ea3n xu\u1ea5t c\u00e1c d\u1ea1ng thu\u1ed1c v\u00e0 thi\u1ebft b\u1ecb y t\u1ebf \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn l\u00e0 m\u1ed9t bi\u1ec7n ph\u00e1p h\u1eefu hi\u1ec7u \u0111\u1ec3 t\u1ea1o ra c\u00e1c s\u1ea3n ph\u1ea9m t\u00f9y ch\u1ec9nh, ph\u00f9 h\u1ee3p v\u1edbi m\u1ee5c \u0111\u00edch \u0111i\u1ec1u tr\u1ecb tr\u00ean t\u1eebng c\u00e1 th\u1ec3 b\u1ec7nh nh\u00e2n, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng \u0111\u1ed1i t\u01b0\u1ee3ng ng\u01b0\u1eddi gi\u00e0 v\u00e0 tr\u1ebb em.
C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 b\u00e0o ch\u1ebf thu\u1ed1c d\u1ef1a tr\u00ean c\u00f4ng ngh\u1ec7 n\u00e0y v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p nh\u01b0 \u0111\u00f4ng r\u1eafn t\u1eeb b\u1ed9t, \u0111\u00f4ng r\u1eafn t\u1eeb ch\u1ea5t l\u1ecfng v\u00e0 \u0111\u00f9n \u00e9p \u0111\u1ec3 t\u1ea1o ra nh\u1eefng s\u1ea3n ph\u1ea9m gi\u1ea3i ph\u00f3ng d\u01b0\u1ee3c ch\u1ea5t theo y\u00eau c\u1ea7u (nhanh, k\u00e9o d\u00e0i ho\u1eb7c c\u00f3 ki\u1ec3m so\u00e1t hay t\u1ea1i \u0111\u00edch\u2026 ). \u0110i\u1ec1u n\u00e0y cho th\u1ea5y, c\u00f4ng ngh\u1ec7 in 3D h\u1ee9a h\u1eb9n \u0111em l\u1ea1i nh\u1eefng \u0111\u1ed9t ph\u00e1 m\u1edbi trong nghi\u00ean c\u1ee9u x\u00e2y d\u1ef1ng c\u00f4ng th\u1ee9c thu\u1ed1c do c\u00f3 th\u1ec3 t\u1ea1o ra c\u00e1c d\u1ea1ng b\u00e0o ch\u1ebf kh\u00e1c nhau v\u1edbi \u0111\u1ed9 ch\u00ednh x\u00e1c cao c\u1ee7a t\u1ef7 l\u1ec7 d\u01b0\u1ee3c ch\u1ea5t v\u00e0 t\u00e1 d\u01b0\u1ee3c theo c\u00e1ch ho\u00e0n to\u00e0n m\u1edbi so v\u1edbi s\u1ea3n xu\u1ea5t d\u01b0\u1ee3c ph\u1ea9m truy\u1ec1n th\u1ed1ng.<\/p>\n\n\n\n

T\u00e0i li\u1ec7u tham kh\u1ea3o<\/span><\/strong><\/p>\n\n\n\n

  1. Lamichhane S.,(2019),\u201cComplex formulations,simple techniques:Can3Dprintingtechnologybe the Midastouch in pharmaceutical industry?\u201dAsian Journal of Pharmaceutic Sciense, Available online 14 February 2019, https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1818087618307852.<\/li>
  2. Jamro\u0301z W., (2018), \u201c3D Printing in Pharmaceutical and Medical Applications \u2013 Recent Achievements and Challenges\u201d, Pharmaceutical research, pp. 35-76<\/li>
  3. Bracaglia LG., ( 2017), \u201cPrinted pericardium hydrogels to promote wound healing in vascular applications\u201d, Biomacromolecules, Vol. 18, pp. 3802\u20133811.<\/li>
  4. Norman J., (2017),\u201cA new chapter in pharmaceutical manufacturing: 3D-printed drug products\u201d, Advanced Drug Delivery Reviews, pp. 39\u201350.<\/li>
  5. Fina F., (2018),\u201cFabricating 3D printed orally disintegrating printlets using selective lasersinterin\u201d, International Journal of Pharmaceutics, V 541, pp. 101-107.<\/li>
  6. Ehtezazi T., Algellay, M., Islam,Y. et al. (2018).\u201cThe application of 3D print- ing in the formulation of multilayered fast dissolving oral films\u201d.Journal of Pharmaceutical Sciences, Vol. 107, pp. 1076-1085.<\/li>
  7. Jamro\u0301z W., (2017), \u201c3D printed orodispersible films with aripiprazole\u201d, International Journal of Pharmaceutics, Vol. 533(2), pp. 413\u201320.<\/li>
  8. Chai X., (2017), Fused deposition modeling (FDM),\u201c3D printed tablets for intragastric floating delivery of domperidone\u201d, Scientificreport 7, https:\/\/www.nature.com\/articles\/s41598-017- 03097-x.<\/li>
  9. Clark E. A., (2017), \u201c3D printing of tablets using inkjet with UV photoinitiation\u201d, International Journal of Pharmaceutics, Vol. 529, pp. 523-530.<\/li>
  10. Okwuosa T. C., (2017), Fabricating a Shell-Core Delayed Release Tablet Using Dual FDM 3D Printing for Patient-Centred Therapy, Pharmaceutical research, Vol. 24, pp. 427-437.<\/li><\/ol>\n\n\n\n

    B\u1ed8 M\u00d4N H\u00d3A D\u01af\u1ee2C – H\u00d3A H\u1eeeU C\u01a0 – H\u00d3A H\u1eccC<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

    Gi\u1edbi thi\u1ec7u v\u1ec1 c\u00f4ng ngh\u1ec7 in 3D Hi\u1ec7n nay, kh\u00e1i ni\u1ec7m \u201cin 3D\u201d(3D printing) \u0111\u00e3 tr\u1edf n\u00ean quen thu\u1ed9c trong nhi\u1ec1u l\u0129nh v\u1ef1c s\u1ea3n xu\u1ea5t. C\u1ee5m t\u1eeb n\u00e0y c\u00f2n \u0111\u1ed3ng […]<\/p>\n","protected":false},"author":82,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":""},"categories":[1796,2267],"tags":[],"yoast_head":"\nC\u00d4NG NGH\u1ec6 IN 3D V\u00c0 M\u1ed8T S\u1ed0 \u1ee8NG D\u1ee4NG TRONG NGHI\u00caN C\u1ee8U THU\u1ed0C - Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Qu\u1ed1c t\u1ebf H\u1ed3ng B\u00e0ng<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/asprou.com\/khoa-duoc\/tin-tuc-khoa-duoc\/cong-nghe-in-3d-va-mot-so-ung-dung-trong-nghien-cuu-thuoc\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"C\u00d4NG NGH\u1ec6 IN 3D V\u00c0 M\u1ed8T S\u1ed0 \u1ee8NG D\u1ee4NG TRONG NGHI\u00caN C\u1ee8U THU\u1ed0C - Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Qu\u1ed1c t\u1ebf H\u1ed3ng B\u00e0ng\" \/>\n<meta property=\"og:description\" content=\"Gi\u1edbi thi\u1ec7u v\u1ec1 c\u00f4ng ngh\u1ec7 in 3D Hi\u1ec7n nay, kh\u00e1i ni\u1ec7m \u201cin 3D\u201d(3D printing) \u0111\u00e3 tr\u1edf n\u00ean quen thu\u1ed9c trong nhi\u1ec1u l\u0129nh v\u1ef1c s\u1ea3n xu\u1ea5t. 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