{"id":59564,"date":"2022-07-04T09:24:43","date_gmt":"2022-07-04T02:24:43","guid":{"rendered":"https:\/\/asprou.com\/?p=59564"},"modified":"2023-04-06T15:46:53","modified_gmt":"2023-04-06T08:46:53","slug":"goc-tu-do-nguon-goc-cua-lao-benh-tu","status":"publish","type":"post","link":"https:\/\/asprou.com\/khoa-duoc\/goc-tu-do-nguon-goc-cua-lao-benh-tu\/","title":{"rendered":"G\u1ed0C T\u1ef0 DO – NGU\u1ed2N G\u1ed0C C\u1ee6A L\u00c3O, B\u1ec6NH, T\u1eec"},"content":{"rendered":"\n

T\u1eeb r\u1ea5t xa x\u01b0a, con ng\u01b0\u1eddi lu\u00f4n \u01b0\u1edbc m\u01a1 v\u00e0 kh\u00f4ng ng\u1eebng t\u00ecm ki\u1ebfm b\u00ed quy\u1ebft tr\u01b0\u1eddng sinh b\u1ea5t t\u1eed. Cho \u0111\u1ebfn nay v\u1eabn ch\u01b0a c\u00f3 ai t\u00ecm \u0111\u01b0\u1ee3c thu\u1ed1c tr\u01b0\u1eddng sinh b\u1ea5t t\u1eed, tuy nhi\u00ean c\u00e1c ti\u1ebfn b\u1ed9 khoa h\u1ecdc k\u1ef9 thu\u1eadt ng\u00e0y nay gi\u00fap con ng\u01b0\u1eddi hi\u1ec3u r\u00f5 c\u01a1 ch\u1ebf l\u00e3o h\u00f3a v\u00e0 c\u00e1c gi\u1ea3i ph\u00e1p n\u00e2ng cao tu\u1ed5i th\u1ecd con ng\u01b0\u1eddi. V\u1eady \u0111i\u1ec1u g\u00ec l\u00e0m cho con ng\u01b0\u1eddi lu\u00f4n ph\u1ea3i \u0111\u1ed1i di\u1ec7n v\u1edbi l\u00e3o ? b\u1ec7nh ? v\u00e0 cu\u1ed1i c\u00f9ng l\u00e0 t\u1eed ? Th\u1ee7 ph\u1ea1m ch\u00ednh l\u00e0 g\u1ed1c t\u1ef1 do (free radical). V\u1eady g\u1ed1c t\u1ef1 do l\u00e0 g\u00ec ? T\u1ea1i sao n\u00f3 l\u1ea1i c\u00f3 s\u1ee9c ph\u00e1 h\u1ee7y l\u1edbn \u0111\u1ebfn nh\u01b0 v\u1eady v\u00e0 l\u00e0m th\u1ebf n\u00e0o \u0111\u1ec3 h\u1ea1n ch\u1ebf c\u00e1c t\u00e1c h\u1ea1i do g\u1ed1c t\u1ef1 do g\u00e2y ra \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe v\u00e0 tu\u1ed5i th\u1ecd c\u1ee7a ch\u00fang ta ?<\/p>\n\n\n\n

G\u1ed1c t\u1ef1 do l\u00e0 g\u00ec ?<\/strong>
G\u1ed1c t\u1ef1 do l\u00e0 nh\u1eefng nguy\u00ean t\u1eed hay ph\u00e2n t\u1eed ch\u1ee9a m\u1ed9t hay nhi\u1ec1u \u0111i\u1ec7n t\u1eed (electron) ch\u01b0a gh\u00e9p c\u1eb7p (electron \u0111\u1ed9c th\u00e2n) \u1edf qu\u1ef9 \u0111\u1ea1o ngo\u00e0i c\u00f9ng. [1] Do s\u1ef1 c\u00f3 m\u1eb7t c\u1ee7a \u0111i\u1ec7n t\u1eed n\u00e0y, c\u00e1c g\u1ed1c t\u1ef1 do c\u00f3 m\u1ed9t thu\u1ed9c t\u00ednh \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng l\u00e0 c\u00f3 kh\u1ea3 n\u0103ng oxi h\u00f3a r\u1ea5t cao. N\u00f3i m\u1ed9t c\u00e1ch kh\u00e1c, b\u1ea5t k\u1ef3 nguy\u00ean t\u1eed hay h\u1ee3p ch\u1ea5t n\u00e0o c\u0169ng ph\u1ea3i c\u00f3 c\u1eb7p electron (\u0111\u00f4i \u0111i\u1ec7n t\u1eed). C\u00f3 \u201c\u0111\u1ee7 c\u1eb7p\u201d th\u00ec n\u00f3 b\u1ec1n, v\u00e0 b\u1ec1n th\u00ec \u201cngoan ngo\u00e3n\u201d, nh\u01b0ng v\u00ec m\u1ed9t s\u1ed1 l\u00fd do, c\u00f3 nh\u1eefng nguy\u00ean t\u1eed (hay ph\u00e2n t\u1eed) thi\u1ebfu \u0111i m\u1ed9t \u0111i\u1ec7n t\u1eed, thi\u1ebfu th\u00ec ph\u1ea3i \u0111i t\u00ecm, v\u00e0 t\u00ecm b\u1eb1ng c\u00e1ch \u201cgi\u1eadt\u201d \u0111i\u1ec7n t\u1eed c\u1ee7a \u201ch\u00e0ng x\u00f3m\u201d, h\u1eadu qu\u1ea3 l\u00e0 h\u00e0ng x\u00f3m thi\u1ebfu, h\u00e0ng x\u00f3m l\u1ea1i \u0111i \u201cgi\u1eadt\u201d ti\u1ebfp \u0111i\u1ec7n t\u1eed, v\u00e0 m\u1ed9t lo\u1ea1t nh\u1eefng h\u00e0nh \u0111\u1ed9ng \u201cc\u01b0\u1edbp\u201d \u0111i\u1ec7n t\u1eed l\u00e0m cho ph\u1ea3n \u1ee9ng c\u1ee9 th\u1ebf x\u1ea3y ra.<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

T\u1ea1i sao g\u1ed1c t\u1ef1 do nguy h\u1ea1i \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe v\u00e0 tu\u1ed5i th\u1ecd con ng\u01b0\u1eddi ?<\/strong>
Trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi, g\u1ed1c t\u1ef1 do \u0111\u01b0\u1ee3c v\u00ed nh\u01b0 nh\u1eefng ph\u1ea7n t\u1eed qu\u00e1 kh\u00edch, \u0111\u1ea7y n\u0103ng l\u01b0\u1ee3ng, t\u1ea5n c\u00f4ng v\u00e0o c\u00e1c \u0111\u1ea1i ph\u00e2n t\u1eed sinh h\u1ecdc nh\u01b0: lipid (g\u00e2y ph\u00e1 h\u1ee7y m\u00e0ng t\u1ebf b\u00e0o), protein (l\u00e0m m\u1ea5t ho\u1ea1t t\u00ednh c\u00e1c enzyme) v\u00e0 ADN (g\u00e2y \u0111\u1ed9t bi\u1ebfn gen), g\u00e2y ra s\u1ef1 l\u00e3o h\u00f3a, nhi\u1ec1u b\u1ec7nh t\u1eadt (x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch, ti\u1ec3u \u0111\u01b0\u1eddng, ch\u1ee9ng thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, c\u00e1c b\u1ec7nh vi\u00eam nhi\u1ec5m: vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, vi\u00eam \u0111\u01b0\u1eddng ru\u1ed9t, vi\u00eam t\u1ee5y\u2026, b\u1ec7nh th\u1ea7n kinh v\u00e0 c\u1ea3 ung th\u01b0. [2, 6]<\/p>\n\n\n\n

G\u1ed1c t\u1ef1 do trong c\u01a1 th\u1ec3 con ng\u01b0\u1eddi \u0111\u1ebfn t\u1eeb \u0111\u00e2u ?<\/strong>
\u0110\u1ed1i v\u1edbi con ng\u01b0\u1eddi, c\u00f3 hai ngu\u1ed3n sinh ra g\u1ed1c t\u1ef1 do. Ngu\u1ed3n n\u1ed9i sinh: \u0111\u00f3 l\u00e0 c\u00e1c ph\u1ea3n \u1ee9ng sinh h\u00f3a trong c\u01a1 th\u1ec3, c\u00e1c ph\u1ea3n \u1ee9ng n\u00e0y c\u00f3 s\u1ef1 tham gia c\u1ee7a oxy v\u00e0 c\u00e1c qu\u00e1 tr\u00ecnh n\u00e0y th\u1ea3i ra m\u1ed9t s\u1ed1 c\u00e1c g\u1ed1c t\u1ef1 do c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb oxy, th\u01b0\u1eddng \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 c\u00e1c d\u1ea1ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a oxy (Reative oxygen species, ROS). [2] Ngo\u00e0i g\u1ed1c t\u1ef1 do n\u1ed9i sinh tr\u00ean, ch\u00fang ta c\u00f2n \u201cti\u1ebfp nh\u1eadn\u201d m\u1ed9t l\u01b0\u1ee3ng g\u1ed1c t\u1ef1 do ngo\u1ea1i sinh: nh\u01b0 t\u1eeb c\u00e1c ngu\u1ed3n \u00f4 nhi\u1ec5m (kh\u00f3i thu\u1ed1c l\u00e1, h\u00f3a ch\u1ea5t, kh\u00f4ng kh\u00ed \u00f4 nhi\u1ec5m \u2026), tia ph\u00f3ng x\u1ea1 (UV, X-quang \u2026), t\u1eeb th\u1ef1c ph\u1ea9m (r\u01b0\u1ee3u, caf\u00e9, th\u1ee9c \u0103n chi\u00ean n\u01b0\u1edbng, ph\u1ee5 gia th\u1ef1c ph\u1ea9m). C\u0103ng th\u1eb3ng (Stress) c\u0169ng l\u00e0 nguy\u00ean nh\u00e2n s\u1ea3n sinh g\u1ed1c t\u1ef1 do. [3, 4, 6]<\/p>\n\n\n\n

L\u00e0m th\u1ebf n\u00e0o \u0111\u1ec3 ch\u1ed1ng l\u1ea1i g\u1ed1c t\u1ef1 do ?<\/strong>
M\u1ed7i ng\u00e0y c\u01a1 th\u1ec3 ch\u00fang ta ph\u1ea3i ch\u1ecbu \u0111\u1ef1ng s\u1ef1 t\u1ea5n c\u00f4ng c\u1ee7a kho\u1ea3ng 10000 -20000 g\u1ed1c t\u1ef1 do, [1] s\u1ed1 l\u01b0\u1ee3ng g\u1ed1c t\u1ef1 do t\u0103ng d\u1ea7n theo tu\u1ed5i t\u00e1c v\u00e0 khi l\u01b0\u1ee3ng g\u1ed1c t\u1ef1 do v\u01b0\u1ee3t ra kh\u1ecfi s\u1ef1 ki\u1ec3m so\u00e1t c\u1ee7a c\u01a1 th\u1ec3 s\u1ebd g\u00e2y ra nh\u1eefng nguy c\u01a1 cao cho s\u1ee9c kh\u1ecfe. V\u00ec v\u1eady \u0111\u00f2i h\u1ecfi ch\u00fang ta ph\u1ea3i b\u1ed5 sung nh\u1eefng ch\u1ea5t ch\u1ea5t c\u00f3 kh\u1ea3 n\u0103ng ch\u1ed1ng l\u1ea1i g\u1ed1c t\u1ef1 do, \u0111\u00f3 l\u00e0 c\u00e1c ch\u1ea5t ch\u1ed1ng oxy h\u00f3a. Ch\u1ea5t ch\u1ed1ng oxy h\u00f3a l\u00e0 ch\u1ea5t c\u00f3 kh\u1ea3 n\u0103ng ng\u0103n ch\u1eb7n ho\u1eb7c h\u1ea1n ch\u1ebf suy tho\u00e1i do c\u00e1c g\u1ed1c t\u1ef1 do g\u00e2y ra. Do \u0111\u00f3 s\u1eed d\u1ee5ng ch\u1ea5t ch\u1ed1ng oxy h\u00f3a t\u1eeb th\u1ee9c \u0103n v\u00e0 ngu\u1ed3n g\u1ed1c sinh h\u1ecdc \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c trung h\u00f2a g\u1ed1c t\u1ef1 do gi\u00fap k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd v\u00e0 ng\u0103n ng\u1eeba b\u1ec7nh t\u1eadt \u1edf ng\u01b0\u1eddi [7].<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

C\u00e1c th\u1ef1c ph\u1ea9m gi\u00e0u ch\u1ea5t ch\u1ed1ng oxy h\u00f3a<\/strong>
C\u00e1c ngu\u1ed3n ch\u1ed1ng oxy h\u00f3a t\u1ef1 nhi\u00ean \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y nhi\u1ec1u trong rau, tr\u00e1i c\u00e2y, c\u00e1c lo\u1ea1i ng\u0169 c\u1ed1c, tr\u00e0, c\u00e1c lo\u1ea1i \u0111\u1eadu\u2026[4] C\u00e1c Vitamin E, Vitamin C v\u00e0 b-caroten (ti\u1ec1n vitamin A) \u0111\u01b0\u1ee3c xem l\u00e0 c\u00e1c ch\u1ea5t ch\u1ed1ng oxy h\u00f3a h\u1eefu hi\u1ec7u trong t\u1ef1 nhi\u00ean.Vitamin E c\u00f3 kh\u1ea3 n\u0103ng ch\u1ed1ng l\u1ea1i c\u00e1c b\u1ec7nh: thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9, \u0111\u1ee5c th\u1ee7y tinh th\u1ec3, vi\u00eam kh\u1edbp, c\u00e1c r\u1ed1i lo\u1ea1n th\u1ea7n kinh, ung th\u01b0 \u0111\u1ea1i tr\u00e0ng, tuy\u1ebfn ti\u1ec1n li\u1ec7t, ung th\u01b0 v\u00fa v\u00e0 c\u00e1c b\u1ec7nh tim m\u1ea1ch\u2026 Vitmin C gi\u00fap t\u0103ng kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch, ch\u1ed1ng x\u01a1 v\u1eefa \u0111\u1ed9ng m\u1ea1ch, gi\u1ea3m kh\u1ea3 n\u0103ng ung th\u01b0 ph\u1ed5i, d\u1ea1 d\u00e0y v\u00e0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng. Nhi\u1ec1u nghi\u00ean c\u1ee9u cho th\u1ea5y h\u01a1n 4000 h\u1ee3p ch\u1ea5t phenolic, polyphenol, flavonoid, isoflavonoid\u2026 c\u0169ng l\u00e0 ngu\u1ed3n ch\u1ed1ng oxy h\u00f3a v\u00f4 c\u00f9ng h\u1eefu hi\u1ec7u, n\u00f3 ng\u0103n ng\u1eeba \u0111\u01b0\u1ee3c r\u1ea5t nhi\u1ec1u c\u0103n b\u1ec7nh g\u00e2y ra b\u1edfi g\u1ed1c t\u1ef1 do: ung th\u01b0, b\u1ec7nh tim m\u1ea1ch,vi\u00eam kh\u1edbp, l\u00e3o h\u00f3a, \u0111\u1ee5c th\u1ee7y tinh th\u1ec3, m\u1ea5t tr\u00ed nh\u1edb, \u0111\u1ed9t qu\u1ef5, b\u1ec7nh Alzheimer, s\u1ef1 vi\u00eam nhi\u1ec5m\u2026. V\u00e0 c\u00e1c h\u1ee3p ch\u1ea5t flavonoid \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y nhi\u1ec1u trong c\u00e1c h\u1ea1t ng\u0169 c\u1ed1c, c\u00e1c lo\u1ea1i \u0111\u1eadu, tr\u00e0\u2026<\/p>\n\n\n\n

Do \u0111\u00f3 \u0111\u1ec3 ch\u1ed1ng l\u1ea1i t\u00e1c h\u1ea1i c\u1ee7a c\u00e1c g\u1ed1c t\u1ef1 do, ch\u00fang ta n\u00ean t\u0103ng c\u01b0\u1eddng ch\u1ebf \u0111\u1ed9 \u0103n nhi\u1ec1u rau xanh v\u00e0 tr\u00e1i c\u00e2y, nh\u01b0 b\u00f4ng c\u1ea3i xanh, c\u00e1c lo\u1ea1i rau c\u00f3 m\u00e0u xanh \u0111\u1eadm, c\u00e1c lo\u1ea1i tr\u00e1i c\u00e2y (d\u00e2u t\u00e2y, qu\u1ea3 vi\u1ec7t qu\u1ed1c, qu\u1ea3 m\u00e2m x\u00f4i, t\u00e1o, nho \u2026). C\u00e1c lo\u1ea1i th\u1ef1c ph\u1ea9m ch\u1ee9a nhi\u1ec1u flavonoid (tr\u00e0, h\u1ea1t cacao, oliu\u2026), c\u00e1c gia v\u1ecb (ngh\u1ec7, g\u1eebng, t\u1ecfi\u2026). Ngo\u00e0i ra m\u1ed9t ch\u1ebf \u0111\u1ed9 \u0103n \u0111\u1ea7y \u0111\u1ee7 protein s\u1ebd cung c\u1ea5p c\u00e1c axit amin c\u1ea7n thi\u1ebft \u0111\u1ec3 s\u1ea3n xu\u1ea5t glutathion (m\u1ed9t ch\u1ea5t ch\u1ed1ng oxy h\u00f3a n\u1ed9i sinh). [8]<\/p>\n\n\n\n

B\u00ed quy\u1ebft s\u1ed1ng kh\u1ecfe v\u00e0 tr\u01b0\u1eddng th\u1ecd<\/strong>
Nh\u01b0 v\u1eady \u0111\u1ec3 k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd, t\u0103ng kh\u1ea3 n\u0103ng ch\u1ed1ng b\u1ec7nh t\u1eadt, ng\u0103n ng\u1eeba s\u1ef1 l\u00e3o h\u00f3a, ch\u00fang ta c\u1ea7n t\u0103ng c\u01b0\u1eddng b\u1ed5 sung c\u00e1c h\u1ee3p ch\u1ea5t c\u00f3 kh\u1ea3 n\u0103ng ch\u1ed1ng oxy h\u00f3a, c\u00e1ch t\u1ed1t nh\u1ea5t l\u00e0 b\u1ed5 sung c\u00e1c ngu\u1ed3n t\u1eeb t\u1ef1 nhi\u00ean, \u0103n \u0111\u00fang, \u0103n \u0111\u1ee7 v\u00e0 \u0103n \u0111a d\u1ea1ng th\u1ef1c ph\u1ea9m. Khi kh\u00f4ng b\u1ec7nh t\u1eadt, qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a \u201cng\u1eebng\u201d x\u1ea3y ra, ch\u00fang ta ho\u00e0n to\u00e0n c\u00f3 th\u1ec3 \u201cm\u01a1\u201d v\u1ec1 gi\u1ea5c m\u01a1 tr\u01b0\u1eddng sinh v\u00e0 bi\u1ebft \u0111\u00e2u \u201cgi\u1ea5c m\u01a1 n\u00e0y\u201d trong t\u01b0\u01a1ng lai, m\u1ed9t ng\u00e0y n\u00e0o \u0111\u00f3 s\u1ebd bi\u1ebfn th\u00e0nh s\u1ef1 th\u1eadt!<\/p>\n\n\n\n

(B\u1ed8 M\u00d4N B\u00c0O CH\u1ebe – H\u00d3A L\u00dd)<\/strong><\/p>\n\n\n\n

T\u00e0i li\u1ec7u tham kh\u1ea3o<\/strong>
[1] Funda Sibel Pala and Hakan G\u00fcrkan. (2008), The role of free radicals in etiopathogenesis of diseases, Advances in Molecular Biology (1): 1-9.
[2] Velavan Sivanandham (2011), Free radicals in health and diseases, Pharmacologyonline 1: 1062-1077.
[3] K.Bagchi and S.Puri.(1998), Free radicals and antioxidants in health and disease, La Revue de Sant\u00e9 de la M\u00e9diterran\u00e9e Orientale, Vol.4, No.2, p.350. <\/p>\n\n\n\n

[4] Saikat Sen and Raja Chakraborty (2011), The Role of Antioxidants in Human Health, ACS Symposium Series, Vol. 1083, Chapter 1, p. 1\u201337,
[5] http:\/\/altered-states.net\/barry\/update227\/
[6] Shiv Kumar (2011), Free Radicals and Antioxidants: Human and Food System, Advances in Applied Science Research, 2 (1): 129-135.
[7] Michael J. Morello1, Fereidoon Shahidi, Chi-Tang Ho, Free Radicals in Foods: Chemistry, Nutrition, and Health Effects, ACS Symposium Series, Vol. 807, Chapter 1, p. 1\u20139.
[8] http:\/\/www.poliquingroup.com\/ArticlesMultimedia\/Articles\/Article\/838\/Do_Antioxidants_Work.aspx.<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u1eeb r\u1ea5t xa x\u01b0a, con ng\u01b0\u1eddi lu\u00f4n \u01b0\u1edbc m\u01a1 v\u00e0 kh\u00f4ng ng\u1eebng t\u00ecm ki\u1ebfm b\u00ed quy\u1ebft tr\u01b0\u1eddng sinh b\u1ea5t t\u1eed. 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