{"id":17857,"date":"2020-05-23T10:40:30","date_gmt":"2020-05-23T03:40:30","guid":{"rendered":"https:\/\/asprou.com\/?p=17857"},"modified":"2020-05-23T11:05:18","modified_gmt":"2020-05-23T04:05:18","slug":"gia-tri-cua-cac-thong-so-sinh-hoa-nuoc-tieu-trong-du-doan-muc-do-nghiem-trong-cua-benh-covid-19","status":"publish","type":"post","link":"https:\/\/asprou.com\/khoa-xnyh\/thong-tin-khoa-hoc-xnyh\/gia-tri-cua-cac-thong-so-sinh-hoa-nuoc-tieu-trong-du-doan-muc-do-nghiem-trong-cua-benh-covid-19\/","title":{"rendered":"Gi\u00e1 tr\u1ecb c\u1ee7a c\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u trong d\u1ef1 \u0111o\u00e1n m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a b\u1ec7nh COVID-19"},"content":{"rendered":"\n
\"\"\/<\/figure><\/div>\n\n\n\n

Gi\u1edbi thi\u1ec7u<\/strong>
Coronavirus l\u00e0 m\u1ed9t lo\u1ea1i RNA virus v\u1edbi h\u1ec7 gen RNA s\u1ee3i d\u01b0\u01a1ng c\u00f3 v\u1ecf b\u1ecdc c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n trong c\u00e1c t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 v\u00e0 ch\u1ee7 y\u1ebfu g\u00e2y nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, bao g\u1ed3m h\u1ed9i ch\u1ee9ng vi\u00eam \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p c\u1ea5p t\u00ednh n\u1eb7ng (SARS) v\u00e0 g\u00e2y b\u00f9ng ph\u00e1t c\u1ea5p c\u1ee7a vi\u00eam ph\u1ebf qu\u1ea3n m\u00e3n t\u00ednh (AECB) \u1edf ng\u01b0\u1eddi v\u00e0 d\u1ecbch SARS-CoV g\u00e2y ra s\u1ef1 ho\u1ea3ng lo\u1ea1n x\u00e3 h\u1ed9i l\u1edbn trong n\u0103m 2003 [1]. M\u1ed9t lo\u1ea1i coronavirus m\u1edbi, \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 SARS-CoV-2 l\u1ea7n \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n v\u00e0o n\u0103m 2019 t\u1ea1i V\u0169 H\u00e1n, Trung Qu\u1ed1c [2]. Virus n\u00e0y l\u00e0 m\u1ed9t ngu\u1ed3n g\u00e2y b\u1ec7nh m\u1edbi \u1edf ng\u01b0\u1eddi v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng l\u00e2y nhi\u1ec5m cho nhi\u1ec1u lo\u00e0i v\u1eadt ch\u1ee7 [3].<\/p>\n\n\n\n

B\u1ec7nh do SARS-CoV-2 g\u00e2y ra \u0111\u01b0\u1ee3c \u0111\u1eb7t t\u00ean l\u00e0 b\u1ec7nh coronavirus 2019 (COVID-19) b\u1edfi WHO [4], v\u00e0 thu\u1eadt ng\u1eef n\u00e0y ch\u1ee7 y\u1ebfu \u0111\u1ec1 c\u1eadp \u0111\u1ebfn s\u1ef1 b\u00f9ng ph\u00e1t c\u1ee7a b\u1ec7nh vi\u00eam ph\u1ed5i do nhi\u1ec5m SARS-CoV-2 \u1edf Trung Qu\u1ed1c [2], [5], [6]. B\u1ec7nh nh\u00e2n m\u1eafc COVID-19 n\u1eb7ng c\u00f3 bi\u1ec3u hi\u1ec7n kh\u00f3 th\u1edf k\u00e8m theo thi\u1ebfu oxy v\u00e0 m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n m\u1eafc h\u1ed9i ch\u1ee9ng suy h\u00f4 h\u1ea5p c\u1ea5p t\u00ednh (ARDS), s\u1ed1c nhi\u1ec5m tr\u00f9ng v\u00e0 suy \u0111a t\u1ea1ng. C\u00e1c k\u1ebft qu\u1ea3 huy\u1ebft h\u1ecdc b\u1ea5t th\u01b0\u1eddng c\u1ee7a b\u1ec7nh nh\u00e2n m\u1eafc COVID-19 bao g\u1ed3m c\u00e1c t\u1ebf b\u00e0o lympho gi\u1ea3m, lactate dehydrogenase (LDH) t\u0103ng, creatine kinase (CK) v\u00e0 c\u00e1c isoenzyme c\u1ee7a n\u00f3 t\u0103ng, protein ph\u1ea3n \u1ee9ng C (CRP) t\u0103ng v\u00e0 c\u00f3 c\u00e1c y\u1ebfu t\u1ed1 g\u00e2y vi\u00eam. C\u00e1c x\u00e9t nghi\u1ec7m h\u00f3a h\u1ecdc tr\u00ean n\u01b0\u1edbc ti\u1ec3u kh\u00f4 c\u00f3 \u0111\u1eb7c \u0111i\u1ec3m l\u00e0 nhanh ch\u00f3ng, thu\u1eadn ti\u1ec7n v\u00e0 kinh t\u1ebf, v\u00e0 c\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a c\u1ee7a n\u01b0\u1edbc ti\u1ec3u c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n h\u1ed7 tr\u1ee3 c\u00e1c nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1eddng ti\u1ebft ni\u1ec7u (UTI) [7 – 9], ch\u1ea9n \u0111o\u00e1n b\u1ec7nh th\u1eadn v\u00e0 theo d\u00f5i hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb. Cho \u0111\u1ebfn nay, ch\u01b0a c\u00f3 b\u00e1o c\u00e1o n\u00e0o v\u1ec1 m\u1ed1i t\u01b0\u01a1ng quan gi\u1eefa c\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u v\u00e0 COVID-19; do \u0111\u00f3, m\u1ee5c \u0111\u00edch c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y l\u00e0 kh\u00e1m ph\u00e1 gi\u00e1 tr\u1ecb c\u1ee7a c\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u trong d\u1ef1 \u0111o\u00e1n m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a COVID-19.<\/p>\n\n\n\n

V\u1eadt li\u1ec7u v\u00e0 ph\u01b0\u01a1ng ph\u00e1p nghi\u00ean c\u1ee9u<\/strong><\/p>\n\n\n\n

Thi\u1ebft k\u1ebf nghi\u00ean c\u1ee9u v\u00e0 ng\u01b0\u1eddi tham gia<\/strong><\/p>\n\n\n\n

Nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t b\u1edfi \u1ee6y ban \u0110\u1ea1o \u0111\u1ee9c Th\u1ec3 ch\u1ebf c\u1ee7a B\u1ec7nh vi\u1ec7n Renmin thu\u1ed9c \u0110\u1ea1i h\u1ecdc V\u0169 H\u00e1n (s\u1ed1 WDRY2020-K066). T\u1ed5ng c\u1ed9ng c\u00f3 119 b\u1ec7nh nh\u00e2n m\u1eafc COVID-19 tham gia v\u00e0o nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n nhi\u1ec5m SARS-CoV-2 t\u1ea1i B\u1ec7nh vi\u1ec7n Renmin
(\u0110\u1ea1i h\u1ecdc V\u0169 H\u00e1n, Trung Qu\u1ed1c) t\u1eeb ng\u00e0y 31 th\u00e1ng 1 \u0111\u1ebfn ng\u00e0y 26 th\u00e1ng 2 n\u0103m 2020 v\u00e0 \u0111\u1ea1i di\u1ec7n cho nh\u00f3m \u0111\u1ed1i ch\u1ee9ng g\u1ed3m 45 ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh. Nh\u00f3m b\u1ec7nh \u0111\u01b0\u1ee3c chia th\u00e0nh ba nh\u00f3m nh\u1ecf (B\u1ea3ng 1) theo Ch\u01b0\u01a1ng tr\u00ecnh ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb vi\u00eam ph\u1ed5i do coronavirus m\u1edbi (phi\u00ean b\u1ea3n th\u1eed
nghi\u1ec7m th\u1ee9 s\u00e1u). B\u1ea5t k\u1ef3 b\u1ec7nh nh\u00e2n ho\u1eb7c ng\u01b0\u1eddi n\u00e0o trong nh\u00f3m ch\u1ee9ng b\u1ecb t\u0103ng huy\u1ebft \u00e1p, ti\u1ec3u \u0111\u01b0\u1eddng, c\u00f3 UTI ho\u1eb7c c\u00e1c b\u1ec7nh kh\u00e1c \u0111\u1ec1u b\u1ecb lo\u1ea1i kh\u1ecfi ph\u00e2n t\u00edch. Th\u00f4ng tin c\u1ee7a b\u1ed1n nh\u00f3m \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea trong B\u1ea3ng 1, cho th\u1ea5y kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3 v\u1ec1 gi\u1edbi t\u00ednh ho\u1eb7c tu\u1ed5i gi\u1eefa b\u1ed1n nh\u00f3m (p > 0,05).<\/p>\n\n\n\n

B\u1ea3ng 1. Th\u00f4ng tin c\u1ee7a nh\u00f3m b\u1ec7nh v\u00e0 nh\u00f3m ch\u1ee9ng<\/p>\n\n\n\n

\"\"\/<\/figure><\/div>\n\n\n\n

Ph\u01b0\u01a1ng ph\u00e1p<\/strong>
Sau khi b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o B\u1ec7nh vi\u1ec7n Renmin, kho\u1ea3ng 20 mL m\u1eabu n\u01b0\u1edbc ti\u1ec3u gi\u1eefa d\u00f2ng s\u1ea1ch \u0111\u01b0\u1ee3c l\u1ea5y t\u1eeb c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng trong m\u1ed7i nh\u00f3m v\u00e0o s\u00e1ng h\u00f4m sau. \u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n COVID-19 nghi\u00eam tr\u1ecdng, c\u00e1c m\u1eabu n\u01b0\u1edbc ti\u1ec3u \u0111\u01b0\u1ee3c thu th\u1eadp qua \u1ed1ng th\u00f4ng. C\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a c\u1ee7a n\u01b0\u1edbc ti\u1ec3u nh\u01b0 m\u00e1u \u1ea9n trong n\u01b0\u1edbc ti\u1ec3u (BLOOD), protein ni\u1ec7u (PRO), bilirubin, urobilinogen, n\u1ed3ng \u0111\u1ed9 hydro (pH), tr\u1ecdng l\u01b0\u1ee3ng ri\u00eang (SG), ketone (KET), glucose n\u01b0\u1edbc ti\u1ec3u (GLU-U), nitrite v\u00e0 b\u1ea1ch c\u1ea7u (LEU) \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m b\u1eb1ng m\u00e1y ph\u00e2n t\u00edch sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u ho\u00e0n to\u00e0n t\u1ef1 \u0111\u1ed9ng (Combi-Scan XL, C\u00f4ng ty C\u00f4ng ngh\u1ec7 Shenzen Baodi, Trung Qu\u1ed1c) v\u00e0 b\u1ed9 d\u1ee5ng c\u1ee5 h\u1ed7 tr\u1ee3 (Combi-UriScreen 11 SYS PLUS, C\u00f4ng ty C\u00f4ng ngh\u1ec7 Shenzen Baodi, Trung Qu\u1ed1c). C\u00e1c tr\u1ea7m t\u00edch n\u01b0\u1edbc ti\u1ec3u \u0111\u01b0\u1ee3c ki\u1ec3m tra b\u1eb1ng m\u00e1y ph\u00e2n t\u00edch tr\u1ea7m t\u00edch t\u1ef1 \u0111\u1ed9ng (Cobio S120, 77 Elektronika Muszeripari Kft, Hungary). T\u1ea5t c\u1ea3 c\u00e1c m\u1eabu thu th\u1eadp \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m trong v\u00f2ng 2 gi\u1edd. Trong tr\u01b0\u1eddng h\u1ee3p ch\u1eadm tr\u1ec5, c\u00e1c m\u1eabu \u0111\u01b0\u1ee3c l\u00e0m l\u1ea1nh. \u0110\u1ec3 c\u00f3 k\u1ebft qu\u1ea3 nghi ng\u1edd, c\u00e1c m\u1eabu \u0111\u01b0\u1ee3c ly t\u00e2m 5 ph\u00fat \u1edf m\u1ee9c 400g v\u00e0 sau \u0111\u00f3 ki\u1ec3m tra b\u1eb1ng k\u00ednh hi\u1ec3n vi c\u1ee7a tr\u1ea7m t\u00edch n\u01b0\u1edbc ti\u1ec3u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi c\u00e1c thanh tra vi\u00ean chuy\u00ean nghi\u1ec7p.<\/p>\n\n\n\n

Ph\u00e2n t\u00edch th\u1ed1ng k\u00ea <\/strong><\/p>\n\n\n\n

Ph\u1ea7n m\u1ec1m th\u1ed1ng k\u00ea SPSS 22.0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ph\u00e2n t\u00edch th\u1ed1ng k\u00ea. D\u1eef li\u1ec7u \u0111o \u0111\u01b0\u1ee3c ph\u00e2n t\u00edch b\u1eb1ng ph\u00e9p th\u1eed chi b\u00ecnh ph\u01b0\u01a1ng (\u03c72). Th\u00f4ng th\u01b0\u1eddng d\u1eef li\u1ec7u \u0111o ph\u00e2n ph\u1ed1i \u0111\u01b0\u1ee3c bi\u1ec3u th\u1ecb b\u1eb1ng gi\u00e1 tr\u1ecb trung b\u00ecnh \u00b1 SD v\u00e0 \u0111\u01b0\u1ee3c ph\u00e2n t\u00edch b\u1eb1ng ph\u00e9p th\u1eed t (t-test) gi\u1eefa hai m\u1eabu. Gi\u00e1 tr\u1ecb p < 0,05 bi\u1ec3u th\u1ecb \u00fd ngh\u0129a th\u1ed1ng k\u00ea.<\/p>\n\n\n\n

C\u00e1c k\u1ebft qu\u1ea3 <\/strong><\/p>\n\n\n\n

Gi\u00e1 tr\u1ecb c\u1ee7a c\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u trong ch\u1ea9n \u0111o\u00e1n COVID-19 <\/strong><\/p>\n\n\n\n

T\u1ef7 l\u1ec7 d\u01b0\u01a1ng t\u00ednh c\u1ee7a BLOOD v\u00e0 PRO cao h\u01a1n \u0111\u00e1ng k\u1ec3 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc COVID-19 so v\u1edbi nh\u00f3m \u0111\u1ed1i ch\u1ee9ng kh\u1ecfe m\u1ea1nh (p < 0,05). S\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 gi\u00e1 tr\u1ecb SG v\u00e0 pH gi\u1eefa b\u1ec7nh nh\u00e2n m\u1eafc COVID-19 v\u00e0 \u0111\u1ed1i ch\u1ee9ng kh\u1ecfe m\u1ea1nh c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea (p < 0,05). C\u00e1c k\u1ebft qu\u1ea3 chi ti\u1ebft \u0111\u01b0\u1ee3c th\u1ec3 hi\u1ec7n trong B\u1ea3ng 2. <\/p>\n\n\n\n

B\u1ea3ng 2. So s\u00e1nh c\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u gi\u1eefa nh\u00f3m b\u1ec7nh nh\u00e2n v\u00e0 nh\u00f3m kh\u1ecfe<\/p>\n\n\n\n

\"\"\/<\/figure><\/div>\n\n\n\n

Gi\u00e1 tr\u1ecb c\u1ee7a c\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u trong vi\u1ec7c ph\u00e2n bi\u1ec7t m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a COVID-19<\/strong><\/p>\n\n\n\n

S\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 t\u1ef7 l\u1ec7 d\u01b0\u01a1ng c\u1ee7a GLU-U v\u00e0 PRO gi\u1eefa c\u00e1c m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng kh\u00e1c nhau c\u1ee7a COVID-19 c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea (p < 0,05). T\u1ef7 l\u1ec7 d\u01b0\u01a1ng t\u00ednh c\u1ee7a GLU-U v\u00e0 PRO cao h\u01a1n \u0111\u00e1ng k\u1ec3 \u1edf nh\u1eefng ng\u01b0\u1eddi b\u1ecb COVID-19 n\u1eb7ng so v\u1edbi nh\u1eefng ng\u01b0\u1eddi m\u1eafc COVID-19 v\u1eeba ph\u1ea3i (p < 0,05). S\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 t\u1ef7 l\u1ec7 ph\u00e1t hi\u1ec7n c\u1ee7a BLOOD, KET, LEU, s\u1ed1 l\u01b0\u1ee3ng h\u1ed3ng c\u1ea7u (RBC) v\u00e0 s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u (WBC) kh\u00f4ng c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea gi\u1eefa c\u00e1c m\u1ee9c \u0111\u1ed9 kh\u00e1c nhau c\u1ee7a COVID-19 (p > 0,05). C\u00e1c k\u1ebft qu\u1ea3 chi ti\u1ebft \u0111\u01b0\u1ee3c th\u1ec3 hi\u1ec7n trong B\u1ea3ng 3. <\/p>\n\n\n\n

B\u1ea3ng 3. \u0110\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a COVID-19 th\u00f4ng qua c\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u<\/p>\n\n\n\n

\"\"\/<\/figure><\/div>\n\n\n\n
\"\"\/<\/figure><\/div>\n\n\n\n

Th\u1ea3o lu\u1eadn<\/strong>
S\u1ef1 b\u00f9ng ph\u00e1t c\u1ee7a d\u1ecbch COVID-19 b\u1eaft \u0111\u1ea7u \u1edf V\u0169 H\u00e1n, Trung Qu\u1ed1c v\u00e0o cu\u1ed1i n\u0103m 2019, \u0111\u00e3 lan r\u1ed9ng tr\u00ean to\u00e0n th\u1ebf gi\u1edbi v\u00e0 d\u1eabn \u0111\u1ebfn m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng l\u1edbn b\u1ec7nh nh\u00e2n t\u1eed vong v\u00e0 thi\u1ec7t h\u1ea1i kinh t\u1ebf l\u1edbn \u1edf Trung Qu\u1ed1c. COVID-19 \u0111\u01b0\u1ee3c WHO x\u00e1c \u0111\u1ecbnh l\u00e0 tr\u01b0\u1eddng h\u1ee3p kh\u1ea9n c\u1ea5p y t\u1ebf c\u1ed9ng \u0111\u1ed3ng th\u1ee9 s\u00e1u \u0111\u01b0\u1ee3c qu\u1ed1c t\u1ebf quan t\u00e2m. Nguy\u00ean nh\u00e2n c\u1ee7a COVID-19 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 SARS-CoV-2 theo ph\u01b0\u01a1ng ph\u00e1p gi\u1ea3i tr\u00ecnh t\u1ef1 gen th\u1ebf h\u1ec7 th\u1ee9 hai d\u1ef1a tr\u00ean RNA [10]. C\u00e1c tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng c\u1ee7a COVID-19 l\u00e0 kh\u00f4ng \u0111\u1eb7c hi\u1ec7u, bao g\u1ed3m ti\u00eau ch\u1ea3y, bu\u1ed3n n\u00f4n, s\u1ed1t, ho v\u00e0 \u0111au c\u01a1, ho\u1eb7c m\u1eafc COVID-19 kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng [11 – 12]. Nh\u1eefng ng\u01b0\u1eddi \u0111\u00e0n \u00f4ng l\u1edbn tu\u1ed5i m\u1eafc b\u1ec7nh \u0111i k\u00e8m c\u00f3 nhi\u1ec1u kh\u1ea3 n\u0103ng b\u1ecb suy h\u00f4 h\u1ea5p v\u00e0 b\u1ec7nh kh\u1edfi ph\u00e1t \u1edf m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n \u0111\u00e3 cho th\u1ea5y s\u1ef1 ti\u1ebfn tri\u1ec3n nhanh ch\u00f3ng \u0111\u1ebfn r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng \u0111a c\u01a1 quan [5]; nhi\u1ec1u b\u1ec7nh nh\u00e2n t\u1eed vong v\u00ec COVID-19 nguy k\u1ecbch.<\/p>\n\n\n\n

Theo Ch\u01b0\u01a1ng tr\u00ecnh Ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0110i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 g\u1ea7n \u0111\u00e2y nh\u1ea5t n\u0103m 2019, ch\u1ee9ng Vi\u00eam ph\u1ed5i coronavirus m\u1edbi (phi\u00ean b\u1ea3n th\u1eed nghi\u1ec7m th\u1ee9 s\u00e1u), b\u1ec7nh nh\u00e2n COVID-19 \u0111\u01b0\u1ee3c chia th\u00e0nh c\u00e1c lo\u1ea1i nh\u1eb9, trung b\u00ecnh, n\u1eb7ng v\u00e0 nguy k\u1ecbch [13]. M\u1ed9t s\u1ed1 th\u00f4ng s\u1ed1 huy\u1ebft h\u1ecdc (v\u00ed d\u1ee5: WBC, gi\u1ea3m b\u1ea1ch c\u1ea7u, CRP, LDH, CK v\u00e0 troponin) c\u00f3 li\u00ean quan \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a COVID-19 [14 – 15].<\/p>\n\n\n\n

Trong nghi\u00ean c\u1ee9u n\u00e0y, t\u1ef7 l\u1ec7 d\u01b0\u01a1ng t\u00ednh c\u1ee7a BLOOD v\u00e0 PRO \u1edf b\u1ec7nh nh\u00e2n COVID-19 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y cao h\u01a1n so v\u1edbi nh\u1eefng ng\u01b0\u1eddi \u1edf nh\u00f3m kh\u1ecfe m\u1ea1nh v\u00e0 gi\u00e1 tr\u1ecb c\u1ee7a SG v\u00e0 pH c\u0169ng kh\u00e1c nhau gi\u1eefa b\u1ec7nh nh\u00e2n COVID-19 v\u00e0 ki\u1ec3m so\u00e1t s\u1ee9c kh\u1ecfe. Tuy nhi\u00ean, t\u1ef7 l\u1ec7 d\u01b0\u01a1ng t\u00ednh c\u1ee7a LEU kh\u00f4ng kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3 gi\u1eefa b\u1ec7nh nh\u00e2n COVID-19 v\u00e0 nh\u00f3m ch\u1ee9ng kh\u1ecfe m\u1ea1nh. K\u1ebft qu\u1ea3 ch\u1ec9 ra r\u1eb1ng s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 BLOOD, PRO, SG v\u00e0 pH l\u00e0 do nhi\u1ec5m SARS-CoV-2, kh\u00f4ng ph\u1ea3i do nhi\u1ec5m vi khu\u1ea9n. B\u1ed1n ch\u1ec9 s\u1ed1 n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 ph\u00e2n bi\u1ec7t b\u1ec7nh nh\u00e2n COVID-19 t\u1eeb nh\u1eefng ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh.<\/p>\n\n\n\n

Do s\u1ed1 l\u01b0\u1ee3ng l\u1edbn b\u1ec7nh nh\u00e2n c\u00f3 tri\u1ec7u ch\u1ee9ng v\u1edbi COVID-19, nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng hi\u1ebfm khi \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb t\u1ea1i b\u1ec7nh vi\u1ec7n v\u00e0 thay v\u00e0o \u0111\u00f3 ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ebfn c\u00e1c \u0111i\u1ec3m c\u00e1ch ly t\u1ea1m th\u1eddi \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb; do \u0111\u00f3, r\u1ea5t kh\u00f3 \u0111\u1ec3 c\u00f3 \u0111\u01b0\u1ee3c th\u00f4ng tin chi ti\u1ebft v\u1ec1 b\u1ec7nh nh\u00e2n kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng. M\u1eb7c d\u00f9 v\u1eady, k\u1ebft qu\u1ea3 sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u v\u1eabn r\u1ea5t \u0111\u00e1ng quan t\u00e2m, v\u00e0 GLU-U v\u00e0 PRO c\u00f3 li\u00ean quan \u0111\u1ebfn m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a COVID-19. T\u1ef7 l\u1ec7 d\u01b0\u01a1ng c\u1ee7a GLU-U v\u00e0 PRO kh\u00e1c nhau \u0111\u00e1ng k\u1ec3 gi\u1eefa c\u00e1c m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng kh\u00e1c nhau c\u1ee7a COVID19. So v\u1edbi b\u1ec7nh nh\u00e2n COVID-19 v\u1eeba ph\u1ea3i, t\u1ef7 l\u1ec7 d\u01b0\u01a1ng t\u00ednh v\u1edbi GLU-U v\u00e0 PRO t\u0103ng \u0111\u00e1ng k\u1ec3 \u1edf nh\u00f3m n\u1eb7ng v\u00e0 nguy k\u1ecbch. Tuy nhi\u00ean, BLOOD, LEU, RBC v\u00e0 WBC cho th\u1ea5y kh\u00f4ng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa c\u00e1c nh\u00f3m trung b\u00ecnh, n\u1eb7ng v\u00e0 nguy k\u1ecbch. Cho th\u1ea5y r\u1eb1ng PRO t\u0103ng cao kh\u00f4ng ph\u1ea3i do nhi\u1ec5m vi khu\u1ea9n trong h\u1ec7 th\u1ed1ng ti\u1ebft ni\u1ec7u, m\u00e0 l\u00e0 do nhi\u1ec5m SARS-CoV-2. ARDS l\u00e0 tri\u1ec7u ch\u1ee9ng ch\u00ednh c\u1ee7a b\u1ec7nh nh\u00e2n m\u1eafc COVID-19 t\u1ea1i Trung Qu\u1ed1c [16] v\u00e0 nhi\u1ec5m SARS-CoV-2 c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nhanh ch\u00f3ng cytokine g\u00e2y ra h\u1ed9i ch\u1ee9ng r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng \u0111a c\u01a1 quan (MODS) bao g\u1ed3m th\u1eadn [17]. T\u1ed5n th\u01b0\u01a1ng th\u1eadn do s\u1ef1 t\u0103ng cao c\u1ee7a cytokine l\u00e0 \u0111i\u1ec1u khi\u1ebfn cho s\u1ef1 kh\u00e1c bi\u1ec7t c\u1ee7a GLU-U v\u00e0 PRO \u1edf ba nh\u00f3m b\u1ec7nh nh\u00e2n COVID-19. H\u01a1n n\u1eefa, t\u1ef7 l\u1ec7 KET d\u01b0\u01a1ng t\u00ednh kh\u00f4ng kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3 gi\u1eefa c\u00e1c m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng kh\u00e1c nhau c\u1ee7a COVID-19, v\u00e0 t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft t\u1ea1m th\u1eddi kh\u00f4ng g\u00e2y ra xu h\u01b0\u1edbng b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh nhi\u1ec5m toan ketone, \u0111i\u1ec1u n\u00e0y gi\u00e1n ti\u1ebfp x\u00e1c minh r\u1eb1ng hi\u1ec7n t\u01b0\u1ee3ng s\u1ed1c \u1edf b\u1ec7nh nh\u00e2n ch\u1ee7 y\u1ebfu l\u00e0 do ch\u1ee9c n\u0103ng ph\u1ed5i b\u1ecb suy y\u1ebfu.<\/p>\n\n\n\n

Trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p n\u00e0y, c\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u kh\u00f4ng ch\u1ec9 h\u1eefu \u00edch trong vi\u1ec7c x\u00e1c \u0111\u1ecbnh COVID-19, m\u00e0 c\u00f2n h\u1eefu \u00edch trong vi\u1ec7c \u0111\u00e1nh gi\u00e1 c\u00e1c thay \u0111\u1ed5i \u0111\u1ed9ng h\u1ecdc \u1edf b\u1ec7nh nh\u00e2n m\u1eafc COVID-19. Do \u0111\u00f3, c\u00e1c t\u00e1c gi\u1ea3 c\u1ee7ng c\u1ed1 \u0111\u1ec1 xu\u1ea5t r\u1eb1ng c\u00e1c x\u00e9t nghi\u1ec7m sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u th\u00f4ng th\u01b0\u1eddng c\u00f3 th\u1ec3 h\u1eefu \u00edch cho vi\u1ec7c \u0111\u00e1nh gi\u00e1 ti\u1ebfn tri\u1ec3n COVID-19.<\/p>\n\n\n\n

B\u00e0i vi\u1ebft \u0111\u01b0\u1ee3c d\u1ecbch t\u1eeb b\u00e1o c\u00e1o nghi\u00ean c\u1ee9u khoa h\u1ecdc:
\u201cThe value of urine biochemical parameters in the prediction of the severity of coronavirus disease 2019\u201d
Nh\u00f3m t\u00e1c gi\u1ea3: Rui Liu, Qingfeng MaORCID iD: https:\/\/orcid.org\/0000-0002-1676-3235, Huan Han, Hanwen Su, Fang Liu, Kailang Wu, Wei Wang and Chengliang Zhu
DOI: https:\/\/doi.org\/10.1515\/cclm-2020-0220| Published online: 14 Apr 2020
https:\/\/www.degruyter.com\/view\/journals\/cclm\/ahead-of-print\/article-10.1515-cclm-2020-0220\/article-10.1515-cclm-2020-0220.xml<\/strong><\/em><\/p>\n\n\n\n

T\u00c0I LI\u1ec6U THAM KH\u1ea2O<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Gi\u1edbi thi\u1ec7uCoronavirus l\u00e0 m\u1ed9t lo\u1ea1i RNA virus v\u1edbi h\u1ec7 gen RNA s\u1ee3i d\u01b0\u01a1ng c\u00f3 v\u1ecf b\u1ecdc c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n […]<\/p>\n","protected":false},"author":13,"featured_media":17862,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":""},"categories":[224],"tags":[430,181,233,433,227],"yoast_head":"\nGi\u00e1 tr\u1ecb c\u1ee7a c\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u trong d\u1ef1 \u0111o\u00e1n m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a b\u1ec7nh COVID-19 - Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Qu\u1ed1c t\u1ebf H\u1ed3ng B\u00e0ng<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/asprou.com\/khoa-xnyh\/thong-tin-khoa-hoc-xnyh\/gia-tri-cua-cac-thong-so-sinh-hoa-nuoc-tieu-trong-du-doan-muc-do-nghiem-trong-cua-benh-covid-19\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gi\u00e1 tr\u1ecb c\u1ee7a c\u00e1c th\u00f4ng s\u1ed1 sinh h\u00f3a n\u01b0\u1edbc ti\u1ec3u trong d\u1ef1 \u0111o\u00e1n m\u1ee9c \u0111\u1ed9 nghi\u00eam tr\u1ecdng c\u1ee7a b\u1ec7nh COVID-19 - 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