{"id":17801,"date":"2020-05-22T21:27:33","date_gmt":"2020-05-22T14:27:33","guid":{"rendered":"https:\/\/asprou.com\/?p=17801"},"modified":"2020-05-27T15:23:11","modified_gmt":"2020-05-27T08:23:11","slug":"mot-so-hieu-biet-ve-cau-truc-cua-virus-corona","status":"publish","type":"post","link":"https:\/\/asprou.com\/khoa-xnyh\/thong-tin-khoa-hoc-xnyh\/mot-so-hieu-biet-ve-cau-truc-cua-virus-corona\/","title":{"rendered":"M\u1ed9t s\u1ed1 hi\u1ec3u bi\u1ebft v\u1ec1 c\u1ea5u tr\u00fac c\u1ee7a Virus Corona"},"content":{"rendered":"\n
\"\"\/<\/figure>\n\n\n\n

C\u00e1c Corona virus \u0111\u00e3 v\u01b0\u1ee3t qua h\u00e0ng r\u00e0o k\u00fd ch\u1ee7 lo\u00e0i v\u00e0 g\u00e2y vi\u00eam ph\u1ed5i t\u1eed vong \u1edf ng\u01b0\u1eddi b\u1eaft \u0111\u1ea7u t\u1eeb th\u1ebf k\u1ef7 21: h\u1ed9i ch\u1ee9ng vi\u00eam \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p c\u1ea5p t\u00ednh do ch\u1ee7ng virus Corona (SARS-CoV)(7, 19), h\u1ed9i ch\u1ee9ng vi\u00eam \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p Trung \u0110\u00f4ng (Middle-East respiratory syndrome coronavirus) (44) (MERS-CoV), v\u00e0 SARS-CoV-2 (14, 46).<\/p>\n\n\n\n

SARS-CoV b\u00f9ng ph\u00e1t \u1edf Guangdong – Trung Qu\u1ed1c n\u0103m 2002 v\u00e0 lan r\u1ed9ng ra n\u0103m ch\u00e2u l\u1ee5c qua \u0111\u01b0\u1eddng du l\u1ecbch h\u00e0ng kh\u00f4ng g\u00e2y nhi\u1ec5m 8.098 v\u00e0 t\u1eed vong 774 ng\u01b0\u1eddi. N\u0103m 2012, MERS-CoV b\u00f9ng ph\u00e1t \u1edf Arabian Peninsula v\u00e0 l\u00e0 v\u1ea5n \u0111\u1ec1 l\u1edbn c\u1ee7a s\u1ee9c kh\u1ecfe c\u1ed9ng \u0111\u1ed3ng, \u0111\u00e3 lan r\u1ed9ng \u0111\u1ebfn 27 qu\u1ed1c gia, g\u00e2y nhi\u1ec5m 2.494 ng\u01b0\u1eddi. <\/p>\n\n\n\n

M\u1ed9t lo\u00e0i virus Corona kh\u00e1c ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn l\u00e0 SARS-CoV-2 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n v\u00e0o th\u00e1ng 12 n\u0103m 2019 t\u1ea1i Wuhan, Hubei \u2013 Trung Qu\u1ed1c v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c gi\u1ea3i tr\u00ecnh t\u1ef1 gen v\u00e0 ph\u00e2n l\u1eadp v\u00e0o th\u00e1ng gi\u00eang n\u0103m 2020(45, 46).<\/p>\n\n\n\n

SARS-CoV-2 c\u00f3 li\u00ean quan \u0111\u1ebfn tr\u1eadn d\u1ecbch vi\u00eam ph\u1ed5i kh\u00f4ng \u0111i\u1ec3n h\u00ecnh \u0111ang x\u1ea3y ra (Covid-2019) v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn tr\u00ean 4 tri\u1ec7u ng\u01b0\u1eddi v\u00e0 \u0111\u00e3 g\u00e2y t\u1eed vong cho tr\u00ean 275.000 ng\u01b0\u1eddi v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u01a1n 200 qu\u1ed1c gia v\u00e0 v\u00f9ng l\u00e3nh th\u1ed5 tr\u00ean to\u00e0n c\u1ea7u t\u00ednh \u0111\u1ebfn ng\u00e0y 9\/5\/2020. <\/p>\n\n\n\n

T\u1ed5 ch\u1ee9c Y T\u1ebf Th\u1ebf Gi\u1edbi \u0111\u00e3 c\u00f4ng b\u1ed1 SARS-CoV-2 l\u00e0 virus g\u00e2y \u0111\u1ea1i d\u1ecbch tr\u00ean to\u00e0n c\u1ea7u v\u00e0o ng\u00e0y 11 th\u00e1ng 3 n\u0103m 2020.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

T\u00ecm hi\u1ec3u v\u1ec1 ngu\u1ed3n g\u1ed1c c\u1ee7a SARS-CoV-2, ng\u01b0\u1eddi ta th\u1ea5y m\u1ed9t s\u1ed1 virus c\u00f3 m\u1ed1i li\u00ean quan, \u0111\u00f3 l\u00e0 MERS-CoV \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb d\u01a1i, nh\u01b0ng v\u1eadt ch\u1ee7 ch\u1ee9a virus g\u00e2y l\u00e2y nhi\u1ec5m cho ng\u01b0\u1eddi v\u1eabn ch\u01b0a r\u00f5(11, 23).<\/p>\n\n\n\n

C\u1ea3 hai virus SARS-CoV v\u00e0 SARS-CoV-2 c\u00f3 nhi\u1ec1u \u0111i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng v\u00e0 \u0111\u1ec1u c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb d\u01a1i(8, 13, 21, 42, 45). Trong khi \u0111\u00f3 c\u1ea7y h\u01b0\u01a1ng v\u00e0 lo\u00e0i ch\u00f3 racoon \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn l\u00e0 v\u1eadt ch\u1ee7 trung gian \u0111\u1ec3 truy\u1ec1n b\u1ec7nh SARS-CoV gi\u1eefa d\u01a1i v\u00e0 ng\u01b0\u1eddi(9, 16, 41) , nh\u01b0ng v\u1edbi SARS-CoV -2 v\u1eadt ch\u1ee7 trung gian v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh ch\u1eafc ch\u1eafn. <\/p>\n\n\n\n

S\u1ef1 lan t\u1ecfa t\u00e1i ph\u00e1t c\u1ee7a Coronavirus \u1edf ng\u01b0\u1eddi c\u00f9ng v\u1edbi vi\u1ec7c ph\u00e1t hi\u1ec7n nhi\u1ec1u Coronavirus \u1edf d\u01a1i, bao g\u1ed3m nhi\u1ec1u Coronavirus li\u00ean quan \u0111\u1ebfn SARS (SARSr-CoV), cho th\u1ea5y vi\u1ec7c l\u00e2y truy\u1ec1n b\u1ec7nh t\u1eeb \u0111\u1ed9ng v\u1eadt sang ng\u01b0\u1eddi trong t\u01b0\u01a1ng lai c\u00f3 th\u1ec3 v\u1eabn c\u00f2n ph\u1ee9c t\u1ea1p. Ngo\u00e0i c\u00e1c virus g\u00e2y b\u1ec7nh n\u1eb7ng nh\u01b0 SARS-CoV, MERS-CoV v\u00e0 SARS-CoV-2, t\u1ea5t c\u1ea3 vir\u00fat c\u00f2n l\u1ea1i \u0111\u1ec1u thu\u1ed9c gi\u1ed1ng Coronavirus. B\u1ed1n lo\u1ea1i Coronavirus g\u00e2y b\u1ec7nh nh\u1eb9 \u1edf
ng\u01b0\u1eddi: HCoV-OC43, HC1V HCoV-NL63 v\u00e0 HCoV-229E. Cho \u0111\u1ebfn nay, kh\u00f4ng c\u00f3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ho\u1eb7c v\u1eafc-xin n\u00e0o \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn \u0111\u1ed1i v\u1edbi b\u1ea5t k\u1ef3 lo\u1ea1i Coronavirus n\u00e0o(2, 8, 13, 21, 24, 25, 42, 45).<\/p>\n\n\n\n

Coronavirus x\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o k\u00fd ch\u1ee7 th\u00f4ng qua glycoprotein xuy\u00ean m\u00e0ng (S). Glycoprotein xuy\u00ean m\u00e0ng t\u1ea1o th\u00e0nh c\u00e1c homotrimers nh\u00f4 ra kh\u1ecfi b\u1ec1 m\u1eb7t virus(34).<\/p>\n\n\n\n

Glycoprotein S bao g\u1ed3m hai ti\u1ec3u \u0111\u01a1n v\u1ecb l\u00e0 ti\u1ec3u \u0111\u01a1n v\u1ecb S1 li\u00ean k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o k\u00fd ch\u1ee7; v\u00e0 ti\u1ec3u \u0111\u01a1n v\u1ecb S2 c\u00f3 ch\u1ee9c n\u0103ng h\u1ee3p nh\u1ea5t m\u00e0ng t\u1ebf b\u00e0o virus v\u00e0 m\u00e0ng t\u1ebf b\u00e0o k\u00fd ch\u1ee7(3, 5, 16, 27, 28, 30, 37).<\/p>\n\n\n\n

\"\"\/<\/figure><\/div>\n\n\n\n

\u0110\u1ed1i v\u1edbi nhi\u1ec1u CoV, glycoprotein S b\u1ecb ph\u00e2n c\u1eaft \u1edf ranh gi\u1edbi gi\u1eefa c\u00e1c ti\u1ec3u \u0111\u01a1n v\u1ecb S1 v\u00e0 S2, n\u01a1i t\u1ed3n t\u1ea1i li\u00ean k\u1ebft kh\u00f4ng \u0111\u1ed3ng h\u00f3a tr\u1ecb trong qu\u00e1 tr\u00ecnh ti\u1ec1n h\u00f2a m\u00e0ng c\u1ee7a virus(10, 17, 29, 33, 37, 43). Ph\u1ea7n xa c\u1ee7a ti\u1ec3u \u0111\u01a1n v\u1ecb S1 c\u00f3 ch\u1ee9a v\u00f9ng li\u00ean k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o k\u00fd ch\u1ee7 v\u00e0 g\u00f3p ph\u1ea7n \u1ed5n \u0111\u1ecbnh tr\u1ea1ng th\u00e1i ti\u1ec1n h\u00f2a m\u00e0ng c\u1ee7a ti\u1ec3u \u0111\u01a1n v\u1ecb S2 khi S2 g\u1eafn v\u00e0o m\u00e0ng t\u1ebf b\u00e0o k\u00fd ch\u1ee7 t\u1ea1i v\u1ecb tr\u00ed c\u00f3 h\u1ec7 th\u1ed1ng h\u00f2a m\u00e0ng (10, 17, 29, 33, 37, 43).<\/p>\n\n\n\n

\u0110\u1ed1i v\u1edbi t\u1ea5t c\u1ea3 c\u00e1c CoV, glycoprotein S ti\u1ebfp t\u1ee5c b\u1ecb c\u1eaft b\u1edfi c\u00e1c protease c\u1ee7a k\u00fd ch\u1ee7 t\u1ea1i v\u1ecb tr\u00ed S2\u2019. S2\u2019 n\u1eb1m ngay ph\u00eda tr\u00ean c\u1ee7a peptide h\u00f2a m\u00e0ng(22, 27). S\u1ef1 ph\u00e2n c\u1eaft n\u00e0y ho\u1ea1t h\u00f3a protein c\u1ea7n cho ph\u1ea3n \u1ee9ng h\u00f2a m\u00e0ng th\u00f4ng qua nh\u1eefng thay \u0111\u1ed5i v\u1ec1 h\u00ecnh d\u1ea1ng kh\u00f4ng th\u1ec3 h\u1ed3i ph\u1ee5c \u0111\u01b0\u1ee3c(3, 12, 42, 43, 30, 39). <\/p>\n\n\n\n

Nh\u01b0 v\u1eady, Coronavirus x\u00e2m nh\u1eadp v\u00e0o c\u00e1c t\u1ebf b\u00e0o nh\u1ea1y c\u1ea3m l\u00e0 m\u1ed9t qu\u00e1 tr\u00ecnh ph\u1ee9c t\u1ea1p \u0111\u00f2i h\u1ecfi ph\u1ea3i c\u00f3 s\u1ef1 ph\u1ed1i h\u1ee3p c\u1ee7a qu\u00e1 tr\u00ecnh li\u00ean k\u1ebft gi\u1eefa virus v\u00e0 th\u1ee5 th\u1ec3 tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o k\u00fd ch\u1ee7 v\u00e0 qu\u00e1 tr\u00ecnh ph\u00e2n gi\u1ea3i glycoprotein S \u0111\u1ec3 th\u00fac \u0111\u1ea9y s\u1ef1 h\u00f2a m\u00e0ng gi\u1eefa virus v\u00e0 t\u1ebf b\u00e0o k\u00fd ch\u1ee7(15, 34, 36).<\/p>\n\n\n\n

C\u00e1c Coronavirus g\u00e2y d\u1ecbch \u0111\u1ecba ph\u01b0\u01a1ng OC43 v\u00e0 HKU1 li\u00ean k\u1ebft v\u00f9ng S (SA) v\u1edbi 5-N-acetyl-9-O-acetyl-sialoside tr\u00ean glycoprotein S v\u1edbi glycolipid tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o k\u00fd ch\u1ee7 \u0111\u1ec3 x\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o nh\u1ea1y c\u1ea3m (15, 34, 36). Trong khi \u0111\u00f3, MERS-CoV S l\u1ea1i s\u1eed d\u1ee5ng v\u00f9ng A (SA) \u0111\u1ec3 nh\u1eadn bi\u1ebft c\u00e1c th\u1ee5 th\u1ec3 sialoside non acetyl h\u00f3a, th\u1ee5 th\u1ec3 n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng th\u00fac \u0111\u1ea9y s\u1ef1 li\u00ean k\u1ebft c\u1ee7a v\u1ee7ng B (SB ) v\u1edbi th\u1ee5 th\u1ec3 x\u00e2m nh\u1eadp l\u00e0 dipeptidyl-peptidase 4(31, 21).<\/p>\n\n\n\n

SARS-CoV v\u00e0 m\u1ed9t s\u1ed1 Coronavirus li\u00ean quan \u0111\u1ebfn SARS (SARSr-CoV) t\u01b0\u01a1ng t\u00e1c tr\u1ef1c ti\u1ebfp v\u1edbi enzyme chuy\u1ec3n \u0111\u1ed5i angiotensin 2 (ACE2) th\u00f4ng qua SB \u0111\u1ec3 x\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o \u0111\u00edch(8, 18, 20, 33, 42).<\/p>\n\n\n\n

V\u00ec glycoprotein S c\u1ee7a Coronavirus ti\u1ebfp x\u00fac v\u1edbi b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o k\u00fd ch\u1ee7 v\u00e0 l\u00e0 v\u1ecb tr\u00ed trung gian \u0111\u1ec3 x\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o k\u00fd ch\u1ee7, n\u00ean n\u00f3 l\u00e0 m\u1ee5c ti\u00eau ch\u00ednh c\u1ee7a s\u1ef1 trung h\u00f2a kh\u00e1ng th\u1ec3 (abs) khi nhi\u1ec5m virus v\u00e0 l\u00e0 \u0111\u1ed1i t\u01b0\u1ee3ng c\u1ee7a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb v\u00e0 nghi\u00ean c\u1ee9u v\u1eafc-xin.
C\u1ea5u tr\u00fac S- trimer \u0111\u01b0\u1ee3c ph\u00e2n b\u1ed1 r\u1ed9ng r\u00e3i v\u1edbi c\u00e1c glycan li\u00ean k\u1ebft N, r\u1ea5t quan tr\u1ecdng cho vi\u1ec7c t\u1ea1o n\u1ebfp g\u1ea5p ch\u00ednh x\u00e1c(32) v\u00e0 \u0111i\u1ec1u h\u00f2a kh\u1ea3 n\u0103ng ti\u1ebfp c\u1eadn v\u1edbi protease c\u1ee7a k\u00fd ch\u1ee7 v\u00e0 kh\u00e1ng th\u1ec3 trung h\u00f2a(38, 40, 42).<\/p>\n\n\n\n

Kh\u00e1ng th\u1ec3 trung h\u00f2a \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb m\u1ed9t s\u1ed1 r\u1ea5t hi\u1ebfm hoi c\u00e1c t\u1ebf b\u00e0o B k\u00fd \u1ee9c c\u1ee7a ng\u01b0\u1eddi b\u1ecb nhi\u1ec5m SARS-CoV(35) ho\u1eb7c nhi\u1ec5m MERS-CoV(6) v\u00e0 c\u1ea1nh tranh \u1ee9c ch\u1ebf kh\u00f4ng cho c\u1ea5u tr\u00fac glycoprotein S B c\u1ee7a virus g\u1eafn v\u00e0o th\u1ee5 th\u1ec3 tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o k\u00fd ch\u1ee7(40).<\/p>\n\n\n\n

Ngo\u00e0i ra, c\u00f2n c\u00f3 c\u01a1 ch\u1ebf li\u00ean k\u1ebft kh\u00e1c gi\u1eefa SARS-CoV-2 v\u00e0 t\u1ebf b\u00e0o k\u00fd ch\u1ee7 l\u00e0 vai tr\u00f2 c\u1ee7a ACE2. SARS-CoV-2 SB t\u01b0\u01a1ng t\u00e1c v\u1edbi ACE2 (hACE2) \u1edf ng\u01b0\u1eddi c\u00f3 \u00e1i l\u1ef1c t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi SARS-CoV SB t\u1eeb c\u00e1c ch\u1ee7ng virus li\u00ean quan \u0111\u1ebfn d\u1ecbch 2002-2003 (t\u1ee9c l\u00e0, li\u00ean k\u1ebft \u00e1i l\u1ef1c cao v\u1edbi hACE2). ACE l\u00e0 enzyme chuy\u1ec3n \u0111\u1ed5i angiotensin.<\/p>\n\n\n\n

\"\"\/<\/figure><\/div>\n\n\n\n

C\u00e1c nghi\u00ean c\u1ee9u kh\u00e1c c\u0169ng cho th\u1ea5y \u0111\u00e2y l\u00e0 virus c\u00f3 v\u1ecf bao, h\u1ea1t virus h\u00ecnh tr\u00f2n ho\u1eb7c b\u1ea7u d\u1ee5c, th\u01b0\u1eddng l\u00e0 \u0111a di\u1ec7n v\u1edbi \u0111\u01b0\u1eddng k\u00ednh 60-140nm. Tr\u00ecnh t\u1ef1 gen c\u1ee7a ch\u1ee7ng virus SARS-CoV-2 bao g\u1ed3m m\u1ed9t chu\u1ed7i RNA \u0111\u01a1n g\u1ed3m 29,903 nucleotide.<\/p>\n\n\n\n

V\u1ec1 m\u1eb7t t\u01b0\u01a1ng \u0111\u1ed3ng, virus SARS-CoV-2 ch\u1ee9a:<\/p>\n\n\n\n

\u2022 50% m\u00e3 gen t\u01b0\u01a1ng \u0111\u1ed3ng v\u1edbi ch\u1ee7ng virus MERS-CoV;
\u2022 79,5% m\u00e3 gen t\u01b0\u01a1ng \u0111\u1ed3ng so v\u1edbi ch\u1ee7ng virus SARS-CoV;
\u2022 96% m\u00e3 gen t\u01b0\u01a1ng \u0111\u1ed3ng so v\u1edbi ch\u1ee7ng virus Corona \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong d\u01a1i, \u0111\u1eb7c bi\u1ec7t l\u00e0 d\u01a1i m\u00f3ng ng\u1ef1a;
\u2022 99% m\u00e3 gen t\u01b0\u01a1ng \u0111\u1ed3ng so v\u1edbi ch\u1ee7ng virus Corona c\u00f3 trong lo\u00e0i T\u00ea t\u00ea<\/p>\n\n\n\n

\u0110i\u1ec1u n\u00e0y cho th\u1ea5y ngu\u1ed3n g\u1ed1c c\u1ee7a virus l\u00e0 \u1edf lo\u00e0i t\u00ea t\u00ea ho\u1eb7c lo\u00e0i d\u01a1i.<\/p>\n\n\n\n

Khi so s\u00e1nh b\u1ed9 gen c\u1ee7a c\u1ea3 alpha v\u00e0 betacoronaviruses (h\u1ecd Coronaviridae) hai \u0111\u1eb7c \u0111i\u1ec3m \u0111\u00e1ng ch\u00fa \u00fd c\u1ee7a b\u1ed9 gen SARS-CoV-2 nh\u01b0 sau:
(i) d\u1ef1a tr\u00ean m\u00f4 h\u00ecnh c\u1ea5u tr\u00fac v\u00e0 c\u00e1c th\u00ed nghi\u1ec7m, SARS-CoV-2 d\u01b0\u1eddng nh\u01b0 \u0111\u01b0\u1ee3c t\u1ed1i \u01b0u h\u00f3a cho li\u00ean k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 ACE2 c\u1ee7a con ng\u01b0\u1eddi;
(ii) protein t\u0103ng \u0111\u1ed9t bi\u1ebfn (S) c\u1ee7a SARS-CoV-2 c\u00f3 v\u1ecb tr\u00ed ph\u00e2n c\u1eaft polybasic (furin) t\u1ea1i ranh gi\u1edbi S1 v\u00e0 S2 th\u00f4ng qua vi\u1ec7c ch\u00e8n th\u00eam v\u00e0o m\u01b0\u1eddi hai nucleotide.<\/p>\n\n\n\n

V\u00f9ng li\u00ean k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 (Receptor-binding domain – RBD) trong protein t\u0103ng \u0111\u1ed9t bi\u1ebfn c\u1ee7a c\u00e1c Coronavirus li\u00ean quan \u0111\u1ebfn SARS-CoV-2 v\u00e0 SARS c\u0169ng l\u00e0 ph\u1ea7n bi\u1ebfn \u0111\u1ed5i nh\u1ea5t trong b\u1ed9 gen c\u1ee7a virus. S\u00e1u v\u00f9ng trong RBD c\u00f3 l\u1ebd r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 li\u00ean k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 ACE2 c\u1ee7a con ng\u01b0\u1eddi v\u00e0 x\u00e1c \u0111\u1ecbnh k\u00fd ch\u1ee7. N\u0103m trong s\u1ed1 s\u00e1u v\u00f9ng n\u00e0y b\u1ecb \u0111\u1ed9t bi\u1ebfn \u1edf SARS-CoV-2 v\u00e0 gi\u1ed1ng \u0111\u1ebfn 96% so v\u1edbi tr\u00ecnh t\u1ef1 gen RaTG13 \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp t\u1eeb d\u01a1i. Ngo\u00e0i
ra, m\u1ed9t s\u1ed1 v\u00f9ng ch\u00ednh trong RBD c\u1ee7a SARS-CoV-2 kh\u00e1c v\u1edbi nh\u1eefng \u0111i\u1ec1u \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 tr\u01b0\u1edbc \u0111\u00e2y v\u00e0 \u0111\u01b0\u1ee3c t\u1ed1i \u01b0u cho li\u00ean k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 ACE2 c\u1ee7a ng\u01b0\u1eddi. C\u00e1c \u0111\u1eb7c \u0111i\u1ec3m b\u1ed9 gen c\u1ee7a SARS-CoV-2 ph\u1ea7n n\u00e0o c\u00f3 th\u1ec3 gi\u1ea3i th\u00edch t\u00ednh l\u00e2y nhi\u1ec5m v\u00e0 kh\u1ea3 n\u0103ng truy\u1ec1n b\u1ec7nh c\u1ee7a SARS-CoV-2 \u1edf ng\u01b0\u1eddi.<\/p>\n\n\n\n

\u0110\u00e1ng ch\u00fa \u00fd h\u01a1n, v\u1ec1 s\u1ef1 bi\u1ebfn \u0111\u1ed5i gen c\u1ee7a vi r\u00fat SARS-CoV-2, c\u00e1c nghi\u00ean c\u1ee9u t\u1ea1i Italy \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u1ed3ng th\u1eddi c\u00f3 4 bi\u1ebfn ch\u1ee7ng c\u1ee7a virus SARS-CoV-2, kh\u00e1c v\u1edbi ch\u1ee7ng c\u1ee7a virus \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh t\u1ea1i V\u0169 H\u00e1n, Trung Qu\u1ed1c (4, 1).<\/p>\n\n\n\n

Tr\u00ean \u0111\u00e2y l\u00e0 m\u1ed9t s\u1ed1 hi\u1ec3u bi\u1ebft v\u1ec1 c\u1ea5u tr\u00fac c\u1ee7a virus Corona v\u00e0 c\u00e1c th\u00f4ng tin n\u00e0y c\u00f3 th\u1ec3 ti\u1ebfp t\u1ee5c \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadt khi c\u00e1c c\u01a1 quan nghi\u00ean c\u1ee9u ti\u1ebfp t\u1ee5c c\u00f4ng b\u1ed1 nh\u1eefng nghi\u00ean c\u1ee9u m\u1edbi h\u01a1n.<\/em><\/strong><\/p>\n\n\n\n

XEM TH\u00caM<\/p>\n\n\n\n

<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

C\u00e1c Corona virus \u0111\u00e3 v\u01b0\u1ee3t qua h\u00e0ng r\u00e0o k\u00fd ch\u1ee7 lo\u00e0i v\u00e0 g\u00e2y vi\u00eam ph\u1ed5i t\u1eed vong \u1edf ng\u01b0\u1eddi b\u1eaft […]<\/p>\n","protected":false},"author":13,"featured_media":17855,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":""},"categories":[224],"tags":[430,181,431,432,234,227],"yoast_head":"\nM\u1ed9t s\u1ed1 hi\u1ec3u bi\u1ebft v\u1ec1 c\u1ea5u tr\u00fac c\u1ee7a Virus Corona - Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Qu\u1ed1c t\u1ebf H\u1ed3ng B\u00e0ng<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/asprou.com\/khoa-xnyh\/thong-tin-khoa-hoc-xnyh\/mot-so-hieu-biet-ve-cau-truc-cua-virus-corona\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"M\u1ed9t s\u1ed1 hi\u1ec3u bi\u1ebft v\u1ec1 c\u1ea5u tr\u00fac c\u1ee7a Virus Corona - 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